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Characterization of DNA Topoisomerase-1 in Spodoptera exigua for Toxicity Evaluation of Camptothecin and Hydoxy-Camptothecin

Camptothecin (CPT), a plant alkaloid originally isolated from the native Chinese tree, Camptotheca acuminate, exerts the toxic effect by targeting eukaryotic DNA topoisomerase 1 (DNA Topo1). Besides as potent anti-cancer agents, CPT and its derivatives are now being explored as potential pesticides...

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Detalles Bibliográficos
Autores principales:	Zhang, Lan, Ma, Dejun, Zhang, Yanning, He, Weizhi, Yang, Jingjing, Li, Chuanren, Jiang, Hongyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579855/ https://www.ncbi.nlm.nih.gov/pubmed/23451051 http://dx.doi.org/10.1371/journal.pone.0056458

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