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Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria

BACKGROUND: While a number of the consequences of mast cell degranulation within tissues have been documented including tissue-specific changes such as bronchospasm and the subsequent cellular infiltrate, there is little known about the immediate effects of mast cell degranulation on the associated...

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Autores principales: Meyer, Joseph, Gorbach, Alexander M., Liu, Wei-Min, Medic, Nevenka, Young, Michael, Nelson, Celeste, Arceo, Sarah, Desai, Avanti, Metcalfe, Dean D., Komarow, Hirsh D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579929/
https://www.ncbi.nlm.nih.gov/pubmed/23451084
http://dx.doi.org/10.1371/journal.pone.0056773
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author Meyer, Joseph
Gorbach, Alexander M.
Liu, Wei-Min
Medic, Nevenka
Young, Michael
Nelson, Celeste
Arceo, Sarah
Desai, Avanti
Metcalfe, Dean D.
Komarow, Hirsh D.
author_facet Meyer, Joseph
Gorbach, Alexander M.
Liu, Wei-Min
Medic, Nevenka
Young, Michael
Nelson, Celeste
Arceo, Sarah
Desai, Avanti
Metcalfe, Dean D.
Komarow, Hirsh D.
author_sort Meyer, Joseph
collection PubMed
description BACKGROUND: While a number of the consequences of mast cell degranulation within tissues have been documented including tissue-specific changes such as bronchospasm and the subsequent cellular infiltrate, there is little known about the immediate effects of mast cell degranulation on the associated vasculature, critical to understanding the evolution of mast cell dependent inflammation. OBJECTIVE: To characterize the microcirculatory events that follow mast cell degranulation. METHODOLOGY/PRINCIPAL FINDINGS: Perturbations in dermal blood flow, temperature and skin color were analyzed using laser-speckle contrast imaging, infrared and polarized-light colorimetry following cold-hand immersion (CHI) challenge in patients with cold-induced urticaria compared to the response in healthy controls. Evidence for mast cell degranulation was established by documentation of serum histamine levels and the localized release of tryptase in post-challenge urticarial biopsies. Laser-speckle contrast imaging quantified the attenuated response to cold challenge in patients on cetirizine. We found that the histamine-associated vascular response accompanying mast cell degranulation is rapid and extensive. At the tissue level, it is characterized by a uniform pattern of increased blood flow, thermal warming, vasodilation, and recruitment of collateral circulation. These vascular responses are modified by the administration of an antihistamine. CONCLUSIONS/SIGNIFICANCE: Monitoring the hemodynamic responses within tissues that are associated with mast cell degranulation provides additional insight into the evolution of the acute inflammatory response and offers a unique approach to assess the effectiveness of treatment intervention.
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spelling pubmed-35799292013-02-28 Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria Meyer, Joseph Gorbach, Alexander M. Liu, Wei-Min Medic, Nevenka Young, Michael Nelson, Celeste Arceo, Sarah Desai, Avanti Metcalfe, Dean D. Komarow, Hirsh D. PLoS One Research Article BACKGROUND: While a number of the consequences of mast cell degranulation within tissues have been documented including tissue-specific changes such as bronchospasm and the subsequent cellular infiltrate, there is little known about the immediate effects of mast cell degranulation on the associated vasculature, critical to understanding the evolution of mast cell dependent inflammation. OBJECTIVE: To characterize the microcirculatory events that follow mast cell degranulation. METHODOLOGY/PRINCIPAL FINDINGS: Perturbations in dermal blood flow, temperature and skin color were analyzed using laser-speckle contrast imaging, infrared and polarized-light colorimetry following cold-hand immersion (CHI) challenge in patients with cold-induced urticaria compared to the response in healthy controls. Evidence for mast cell degranulation was established by documentation of serum histamine levels and the localized release of tryptase in post-challenge urticarial biopsies. Laser-speckle contrast imaging quantified the attenuated response to cold challenge in patients on cetirizine. We found that the histamine-associated vascular response accompanying mast cell degranulation is rapid and extensive. At the tissue level, it is characterized by a uniform pattern of increased blood flow, thermal warming, vasodilation, and recruitment of collateral circulation. These vascular responses are modified by the administration of an antihistamine. CONCLUSIONS/SIGNIFICANCE: Monitoring the hemodynamic responses within tissues that are associated with mast cell degranulation provides additional insight into the evolution of the acute inflammatory response and offers a unique approach to assess the effectiveness of treatment intervention. Public Library of Science 2013-02-22 /pmc/articles/PMC3579929/ /pubmed/23451084 http://dx.doi.org/10.1371/journal.pone.0056773 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Meyer, Joseph
Gorbach, Alexander M.
Liu, Wei-Min
Medic, Nevenka
Young, Michael
Nelson, Celeste
Arceo, Sarah
Desai, Avanti
Metcalfe, Dean D.
Komarow, Hirsh D.
Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria
title Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria
title_full Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria
title_fullStr Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria
title_full_unstemmed Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria
title_short Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria
title_sort mast cell dependent vascular changes associated with an acute response to cold immersion in primary contact urticaria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579929/
https://www.ncbi.nlm.nih.gov/pubmed/23451084
http://dx.doi.org/10.1371/journal.pone.0056773
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