Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse

The integrity of male germ cell genome is critical for the correct progression of spermatogenesis, successful fertilization, and proper development of the offspring. Several DNA repair pathways exist in male germ cells. However, unlike somatic cells, key components of such pathways remain largely un...

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Detalles Bibliográficos
Autores principales: Jamsai, Duangporn, O’Connor, Anne E., DeBoer, Kathleen D., Clark, Brett J., Smith, Stephanie J., Browne, Catherine M., Bensley, Jonathan G., Merriman, Julie A., Yuen, Wai Shan, Koopman, Peter, Jones, Keith T., O’Bryan, Moira K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579931/
https://www.ncbi.nlm.nih.gov/pubmed/23451117
http://dx.doi.org/10.1371/journal.pone.0056955

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