C9orf72 immunohistochemistry in Alzheimer's disease

Mutation in chromosome 9 open reading frame 72 (C9orf72) is a major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), referred to as C9FTD/ALS. The function of the protein is currently unknown, and the pathomechanism of C9FTD/ALS remains to be elucidated. The st...

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Autor principal: Hortobágyi, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580394/
https://www.ncbi.nlm.nih.gov/pubmed/23014271
http://dx.doi.org/10.1186/alzrt140
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author Hortobágyi, Tibor
author_facet Hortobágyi, Tibor
author_sort Hortobágyi, Tibor
collection PubMed
description Mutation in chromosome 9 open reading frame 72 (C9orf72) is a major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), referred to as C9FTD/ALS. The function of the protein is currently unknown, and the pathomechanism of C9FTD/ALS remains to be elucidated. The study by Satoh and colleagues in the previous issue of Alzheimer's Research & Therapy presents important new findings on C9orf72 protein expression in neurodegenerative disorders along with characterization of C9orf72 antibodies.
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spelling pubmed-35803942013-03-26 C9orf72 immunohistochemistry in Alzheimer's disease Hortobágyi, Tibor Alzheimers Res Ther Commentary Mutation in chromosome 9 open reading frame 72 (C9orf72) is a major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), referred to as C9FTD/ALS. The function of the protein is currently unknown, and the pathomechanism of C9FTD/ALS remains to be elucidated. The study by Satoh and colleagues in the previous issue of Alzheimer's Research & Therapy presents important new findings on C9orf72 protein expression in neurodegenerative disorders along with characterization of C9orf72 antibodies. BioMed Central 2012-09-26 /pmc/articles/PMC3580394/ /pubmed/23014271 http://dx.doi.org/10.1186/alzrt140 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Commentary
Hortobágyi, Tibor
C9orf72 immunohistochemistry in Alzheimer's disease
title C9orf72 immunohistochemistry in Alzheimer's disease
title_full C9orf72 immunohistochemistry in Alzheimer's disease
title_fullStr C9orf72 immunohistochemistry in Alzheimer's disease
title_full_unstemmed C9orf72 immunohistochemistry in Alzheimer's disease
title_short C9orf72 immunohistochemistry in Alzheimer's disease
title_sort c9orf72 immunohistochemistry in alzheimer's disease
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580394/
https://www.ncbi.nlm.nih.gov/pubmed/23014271
http://dx.doi.org/10.1186/alzrt140
work_keys_str_mv AT hortobagyitibor c9orf72immunohistochemistryinalzheimersdisease

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