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Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data

BACKGROUND: Telomeres are the protective arrays of tandem TTAGGG sequence and associated proteins at the termini of chromosomes. Telomeres shorten at each cell division due to the end-replication problem and are maintained above a critical threshold in malignant cancer cells to prevent cellular sene...

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Detalles Bibliográficos
Autores principales:	Parker, Matthew, Chen, Xiang, Bahrami, Armita, Dalton, James, Rusch, Michael, Wu, Gang, Easton, John, Cheung, Nai-Kong, Dyer, Michael, Mardis, Elaine R, Wilson, Richard K, Mullighan, Charles, Gilbertson, Richard, Baker, Suzanne J, Zambetti, Gerard, Ellison, David W, Downing, James R, Zhang, Jinghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580411/ https://www.ncbi.nlm.nih.gov/pubmed/23232254 http://dx.doi.org/10.1186/gb-2012-13-12-r113

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