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Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

INTRODUCTION: A substantial number of therapeutic drugs for Alzheimer's disease (AD) have failed in late-stage trials, highlighting the translational disconnect with pathology-based animal models. METHODS: To bridge the gap between preclinical animal models and clinical outcomes, we implemented...

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Detalles Bibliográficos
Autores principales:	Roberts, Patrick D, Spiros, Athan, Geerts, Hugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580459/ https://www.ncbi.nlm.nih.gov/pubmed/23181523 http://dx.doi.org/10.1186/alzrt153

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