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HIF-2α - a mediator of stem cell altruism?
Human embryonic stem cells (hESCs) have been reported to confer cytoprotection in the context of tissue injury. This is somewhat counterintuitive given that microenvironmental factors such as hypoxia and oxidative stress may activate p53 and result in death and differentiation of these hESCs. In thi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580482/ https://www.ncbi.nlm.nih.gov/pubmed/23253294 http://dx.doi.org/10.1186/scrt143 |
| _version_ | 1782260258028126208 |
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| author | Cummins, Eoin P |
| author_facet | Cummins, Eoin P |
| author_sort | Cummins, Eoin P |
| collection | PubMed |
| description | Human embryonic stem cells (hESCs) have been reported to confer cytoprotection in the context of tissue injury. This is somewhat counterintuitive given that microenvironmental factors such as hypoxia and oxidative stress may activate p53 and result in death and differentiation of these hESCs. In this article, we discuss a novel mechanism through which hESCs can be re-programmed (through exposure to hypoxia/oxidative stress) to transiently suppress p53, enhance 'stemness', and exist in a highly cytoprotective and undifferentiated state. |
| format | Online Article Text |
| id | pubmed-3580482 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-35804822013-12-18 HIF-2α - a mediator of stem cell altruism? Cummins, Eoin P Stem Cell Res Ther Commentary Human embryonic stem cells (hESCs) have been reported to confer cytoprotection in the context of tissue injury. This is somewhat counterintuitive given that microenvironmental factors such as hypoxia and oxidative stress may activate p53 and result in death and differentiation of these hESCs. In this article, we discuss a novel mechanism through which hESCs can be re-programmed (through exposure to hypoxia/oxidative stress) to transiently suppress p53, enhance 'stemness', and exist in a highly cytoprotective and undifferentiated state. BioMed Central 2012-12-18 /pmc/articles/PMC3580482/ /pubmed/23253294 http://dx.doi.org/10.1186/scrt143 Text en Copyright ©2012 BioMed Central Ltd |
| spellingShingle | Commentary Cummins, Eoin P HIF-2α - a mediator of stem cell altruism? |
| title | HIF-2α - a mediator of stem cell altruism? |
| title_full | HIF-2α - a mediator of stem cell altruism? |
| title_fullStr | HIF-2α - a mediator of stem cell altruism? |
| title_full_unstemmed | HIF-2α - a mediator of stem cell altruism? |
| title_short | HIF-2α - a mediator of stem cell altruism? |
| title_sort | hif-2α - a mediator of stem cell altruism? |
| topic | Commentary |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580482/ https://www.ncbi.nlm.nih.gov/pubmed/23253294 http://dx.doi.org/10.1186/scrt143 |
| work_keys_str_mv | AT cumminseoinp hif2aamediatorofstemcellaltruism |