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Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation?
Mesenchymal stem cells change dramatically during culture expansion. Long-term culture has been suspected to evoke oncogenic transformation: overall, the genome appears to be relatively stable throughout culture but transient clonal aneuploidies have been observed. Oncogenic transformation does not...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580484/ https://www.ncbi.nlm.nih.gov/pubmed/23257053 http://dx.doi.org/10.1186/scrt145 |