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Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity
INTRODUCTION: A role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE. METHODS:...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580530/ https://www.ncbi.nlm.nih.gov/pubmed/23068019 http://dx.doi.org/10.1186/ar4057 |
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author | Panda, Aditya K Parida, Jyoti R Tripathy, Rina Pattanaik, Sarit S Ravindran, Balachandran Das, Bidyut K |
author_facet | Panda, Aditya K Parida, Jyoti R Tripathy, Rina Pattanaik, Sarit S Ravindran, Balachandran Das, Bidyut K |
author_sort | Panda, Aditya K |
collection | PubMed |
description | INTRODUCTION: A role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE. METHODS: In a case control study SLE patients (93 females) and 67 age, sex, ethnicity matched healthy controls were enrolled. Plasma MBL levels were quantified by enzyme linked immunosorbent assay (ELISA). Clinical, serological and other markers of disease activity (C3, C4 and anti-dsDNA) were measured by standard laboratory procedures. RESULTS: Plasma MBL levels were significantly high in SLE patients compared to healthy controls (P < 0.0001). MBL levels were variable in different clinical categories of SLE. Lower levels were associated with musculoskeletal and cutaneous manifestations (P = 0.002), while higher and intermediate MBL levels were significantly associated with nephritis in combination with other systemic manifestations (P = 0.01 and P = 0.04 respectively). Plasma MBL correlated with systemic lupus erythematosus disease activity index (SLEDAI) (P = 0.0003, r = 0.36), anti-dsDNA (P < 0.0001, r = 0.54), proteinuria (P < 0.0001, r = 0.42) and negatively correlated with C3 (P = 0.007, r = -0.27) and C4 (P = 0.01, r = -0.29). CONCLUSIONS: Plasma MBL is a promising marker in the assessment of SLE disease activity. |
format | Online Article Text |
id | pubmed-3580530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35805302013-02-26 Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity Panda, Aditya K Parida, Jyoti R Tripathy, Rina Pattanaik, Sarit S Ravindran, Balachandran Das, Bidyut K Arthritis Res Ther Research Article INTRODUCTION: A role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE. METHODS: In a case control study SLE patients (93 females) and 67 age, sex, ethnicity matched healthy controls were enrolled. Plasma MBL levels were quantified by enzyme linked immunosorbent assay (ELISA). Clinical, serological and other markers of disease activity (C3, C4 and anti-dsDNA) were measured by standard laboratory procedures. RESULTS: Plasma MBL levels were significantly high in SLE patients compared to healthy controls (P < 0.0001). MBL levels were variable in different clinical categories of SLE. Lower levels were associated with musculoskeletal and cutaneous manifestations (P = 0.002), while higher and intermediate MBL levels were significantly associated with nephritis in combination with other systemic manifestations (P = 0.01 and P = 0.04 respectively). Plasma MBL correlated with systemic lupus erythematosus disease activity index (SLEDAI) (P = 0.0003, r = 0.36), anti-dsDNA (P < 0.0001, r = 0.54), proteinuria (P < 0.0001, r = 0.42) and negatively correlated with C3 (P = 0.007, r = -0.27) and C4 (P = 0.01, r = -0.29). CONCLUSIONS: Plasma MBL is a promising marker in the assessment of SLE disease activity. BioMed Central 2012 2012-10-15 /pmc/articles/PMC3580530/ /pubmed/23068019 http://dx.doi.org/10.1186/ar4057 Text en Copyright ©2012 Panda et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Panda, Aditya K Parida, Jyoti R Tripathy, Rina Pattanaik, Sarit S Ravindran, Balachandran Das, Bidyut K Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity |
title | Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity |
title_full | Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity |
title_fullStr | Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity |
title_full_unstemmed | Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity |
title_short | Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity |
title_sort | mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580530/ https://www.ncbi.nlm.nih.gov/pubmed/23068019 http://dx.doi.org/10.1186/ar4057 |
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