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Enhanced interleukin-1β production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals

INTRODUCTION: Monosodium urate monohydrate (MSU) crystals synergize with various toll-like receptor (TLR) ligands to induce cytokine production via activation of the NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLPR3) inflammasome. This has been demonstrated in vitro using human cell l...

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Detalles Bibliográficos
Autores principales:	Mylona, Eleni E, Mouktaroudi, Maria, Crisan, Tania O, Makri, Stamatoula, Pistiki, Aikaterini, Georgitsi, Marianna, Savva, Athina, Netea, Mihai G, van der Meer, Jos WM, Giamarellos-Bourboulis, Evangelos J, Joosten, Leo AB
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580550/ https://www.ncbi.nlm.nih.gov/pubmed/22762240 http://dx.doi.org/10.1186/ar3898

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