How much fluid resuscitation is optimal in septic shock?

ABSTRACT: Smith and Perner report an observational cohort study of 164 patients with septic shock. For patients still alive on day 3, higher compared with lower fluid volume resuscitation was associated with lower 90-day mortality. This association of a relationship between fluid intake and decrease...

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Detalles Bibliográficos
Autor principal: Russell, James A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580685/
https://www.ncbi.nlm.nih.gov/pubmed/22873642
http://dx.doi.org/10.1186/cc11393
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author Russell, James A
author_facet Russell, James A
author_sort Russell, James A
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description ABSTRACT: Smith and Perner report an observational cohort study of 164 patients with septic shock. For patients still alive on day 3, higher compared with lower fluid volume resuscitation was associated with lower 90-day mortality. This association of a relationship between fluid intake and decreased mortality aligns with the randomized controlled trial of early goal-directed therapy and later observational studies. I suggest careful individualization of fluid resuscitation to achieve adequate mean arterial pressure (about 60 to 70 mmHg) and normalization of arterial lactate levels in septic shock. TRIAL REGISTRATION: ISRCTN94845869
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spelling pubmed-35806852013-08-08 How much fluid resuscitation is optimal in septic shock? Russell, James A Crit Care Commentary ABSTRACT: Smith and Perner report an observational cohort study of 164 patients with septic shock. For patients still alive on day 3, higher compared with lower fluid volume resuscitation was associated with lower 90-day mortality. This association of a relationship between fluid intake and decreased mortality aligns with the randomized controlled trial of early goal-directed therapy and later observational studies. I suggest careful individualization of fluid resuscitation to achieve adequate mean arterial pressure (about 60 to 70 mmHg) and normalization of arterial lactate levels in septic shock. TRIAL REGISTRATION: ISRCTN94845869 BioMed Central 2012 2012-08-08 /pmc/articles/PMC3580685/ /pubmed/22873642 http://dx.doi.org/10.1186/cc11393 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Commentary
Russell, James A
How much fluid resuscitation is optimal in septic shock?
title How much fluid resuscitation is optimal in septic shock?
title_full How much fluid resuscitation is optimal in septic shock?
title_fullStr How much fluid resuscitation is optimal in septic shock?
title_full_unstemmed How much fluid resuscitation is optimal in septic shock?
title_short How much fluid resuscitation is optimal in septic shock?
title_sort how much fluid resuscitation is optimal in septic shock?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580685/
https://www.ncbi.nlm.nih.gov/pubmed/22873642
http://dx.doi.org/10.1186/cc11393
work_keys_str_mv AT russelljamesa howmuchfluidresuscitationisoptimalinsepticshock

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