Cargando…
Free haemoglobin in 'old' transfused blood - baddy or bystander?
In the previous issue of Critical Care, Vermeulen Windsant and colleagues demonstrate that transfusion of packed red cells is associated with a transient increase in plasma free haemoglobin and scavenging of nitric oxide in vitro. They also demonstrate that older units of blood have more free haemog...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580694/ https://www.ncbi.nlm.nih.gov/pubmed/22849612 http://dx.doi.org/10.1186/cc11411 |
_version_ | 1782260309454487552 |
---|---|
author | Finney, Simon J |
author_facet | Finney, Simon J |
author_sort | Finney, Simon J |
collection | PubMed |
description | In the previous issue of Critical Care, Vermeulen Windsant and colleagues demonstrate that transfusion of packed red cells is associated with a transient increase in plasma free haemoglobin and scavenging of nitric oxide in vitro. They also demonstrate that older units of blood have more free haemoglobin in their supernatants. Whether the administration of older stored blood results in adverse clinical outcomes is a topical clinical question. The present study proposes a mechanism for transfusion-related harm but also has implications for patients who have other sources of free haemoglobin in their circulation. |
format | Online Article Text |
id | pubmed-3580694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35806942013-07-31 Free haemoglobin in 'old' transfused blood - baddy or bystander? Finney, Simon J Crit Care Commentary In the previous issue of Critical Care, Vermeulen Windsant and colleagues demonstrate that transfusion of packed red cells is associated with a transient increase in plasma free haemoglobin and scavenging of nitric oxide in vitro. They also demonstrate that older units of blood have more free haemoglobin in their supernatants. Whether the administration of older stored blood results in adverse clinical outcomes is a topical clinical question. The present study proposes a mechanism for transfusion-related harm but also has implications for patients who have other sources of free haemoglobin in their circulation. BioMed Central 2012 2012-07-31 /pmc/articles/PMC3580694/ /pubmed/22849612 http://dx.doi.org/10.1186/cc11411 Text en Copyright ©2012 BioMed Central Ltd |
spellingShingle | Commentary Finney, Simon J Free haemoglobin in 'old' transfused blood - baddy or bystander? |
title | Free haemoglobin in 'old' transfused blood - baddy or bystander? |
title_full | Free haemoglobin in 'old' transfused blood - baddy or bystander? |
title_fullStr | Free haemoglobin in 'old' transfused blood - baddy or bystander? |
title_full_unstemmed | Free haemoglobin in 'old' transfused blood - baddy or bystander? |
title_short | Free haemoglobin in 'old' transfused blood - baddy or bystander? |
title_sort | free haemoglobin in 'old' transfused blood - baddy or bystander? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580694/ https://www.ncbi.nlm.nih.gov/pubmed/22849612 http://dx.doi.org/10.1186/cc11411 |
work_keys_str_mv | AT finneysimonj freehaemoglobininoldtransfusedbloodbaddyorbystander |