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Genome maintenance and transcription integrity in aging and disease

DNA damage contributes to cancer development and aging. Congenital syndromes that affect DNA repair processes are characterized by cancer susceptibility, developmental defects, and accelerated aging (Schumacher et al., 2008). DNA damage interferes with DNA metabolism by blocking replication and tran...

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Detalles Bibliográficos
Autores principales: Wolters, Stefanie, Schumacher, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580961/
https://www.ncbi.nlm.nih.gov/pubmed/23443494
http://dx.doi.org/10.3389/fgene.2013.00019