Cargando…

Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis

PURPOSE: To evaluate the precise association of complement factor H (CFH) Val62Ile polymorphism with age-related macular degeneration (AMD) susceptibility. METHODS: We performed a meta-analysis using databases including PubMed, EMBASE, and Web of Science to find relevant studies. Summary odds ratios...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Dongqing, Yang, Qin, Liu, Xiaoyi, Yuan, Donglan, Yuan, Songtao, Xie, Ping, Liu, Qinghuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580987/
https://www.ncbi.nlm.nih.gov/pubmed/23441108
_version_ 1782260357344002048
author Yuan, Dongqing
Yang, Qin
Liu, Xiaoyi
Yuan, Donglan
Yuan, Songtao
Xie, Ping
Liu, Qinghuai
author_facet Yuan, Dongqing
Yang, Qin
Liu, Xiaoyi
Yuan, Donglan
Yuan, Songtao
Xie, Ping
Liu, Qinghuai
author_sort Yuan, Dongqing
collection PubMed
description PURPOSE: To evaluate the precise association of complement factor H (CFH) Val62Ile polymorphism with age-related macular degeneration (AMD) susceptibility. METHODS: We performed a meta-analysis using databases including PubMed, EMBASE, and Web of Science to find relevant studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed-effect and random-effects models. The inconsistency index (I(2)) was used to assess heterogeneity. Funnel plots and Egger’s test were used to evaluate publication bias. Sensitivity analysis was also performed. RESULTS: Fourteen studies including 4,438 patients with AMD and 6,099 controls based on the search criteria were involved in the meta-analysis. In overall populations, the pooled OR(1) for genotype GA+GG versus homozygous genotype AA was 2.28 (95% confidence interval (CI): 1.48–3.52), the OR(2) of heterozygous genotype GA versus AA was 1.58 (95% CI: 1.13–2.19), the OR(3) of homozygous genotype GG versus AA was 2.90 (95% CI: 1.95–4.30), and the OR(4) of allele G versus A was 1.77 (95% CI: 1.43–2.21). In Asian populations, our results provided substantial evidence that the Val62Ile variant was significantly associated with AMD (OR(4)=1.85, 95% CI: 1.63–2.09). However, in Caucasian populations, no significant association of Val62Ile with AMD was established in all circumstances. CONCLUSIONS: Our analysis provides substantial evidence that the Val62Ile variant is significantly associated with AMD in Asian populations. However, our results have demonstrated no link between the Val62Ile polymorphism and AMD in Caucasian populations.
format Online
Article
Text
id pubmed-3580987
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Molecular Vision
record_format MEDLINE/PubMed
spelling pubmed-35809872013-02-25 Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis Yuan, Dongqing Yang, Qin Liu, Xiaoyi Yuan, Donglan Yuan, Songtao Xie, Ping Liu, Qinghuai Mol Vis Research Article PURPOSE: To evaluate the precise association of complement factor H (CFH) Val62Ile polymorphism with age-related macular degeneration (AMD) susceptibility. METHODS: We performed a meta-analysis using databases including PubMed, EMBASE, and Web of Science to find relevant studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed-effect and random-effects models. The inconsistency index (I(2)) was used to assess heterogeneity. Funnel plots and Egger’s test were used to evaluate publication bias. Sensitivity analysis was also performed. RESULTS: Fourteen studies including 4,438 patients with AMD and 6,099 controls based on the search criteria were involved in the meta-analysis. In overall populations, the pooled OR(1) for genotype GA+GG versus homozygous genotype AA was 2.28 (95% confidence interval (CI): 1.48–3.52), the OR(2) of heterozygous genotype GA versus AA was 1.58 (95% CI: 1.13–2.19), the OR(3) of homozygous genotype GG versus AA was 2.90 (95% CI: 1.95–4.30), and the OR(4) of allele G versus A was 1.77 (95% CI: 1.43–2.21). In Asian populations, our results provided substantial evidence that the Val62Ile variant was significantly associated with AMD (OR(4)=1.85, 95% CI: 1.63–2.09). However, in Caucasian populations, no significant association of Val62Ile with AMD was established in all circumstances. CONCLUSIONS: Our analysis provides substantial evidence that the Val62Ile variant is significantly associated with AMD in Asian populations. However, our results have demonstrated no link between the Val62Ile polymorphism and AMD in Caucasian populations. Molecular Vision 2013-02-13 /pmc/articles/PMC3580987/ /pubmed/23441108 Text en Copyright © 2013 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yuan, Dongqing
Yang, Qin
Liu, Xiaoyi
Yuan, Donglan
Yuan, Songtao
Xie, Ping
Liu, Qinghuai
Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis
title Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis
title_full Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis
title_fullStr Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis
title_full_unstemmed Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis
title_short Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis
title_sort complement factor h val62ile variant and risk of age-related macular degeneration: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580987/
https://www.ncbi.nlm.nih.gov/pubmed/23441108
work_keys_str_mv AT yuandongqing complementfactorhval62ilevariantandriskofagerelatedmaculardegenerationametaanalysis
AT yangqin complementfactorhval62ilevariantandriskofagerelatedmaculardegenerationametaanalysis
AT liuxiaoyi complementfactorhval62ilevariantandriskofagerelatedmaculardegenerationametaanalysis
AT yuandonglan complementfactorhval62ilevariantandriskofagerelatedmaculardegenerationametaanalysis
AT yuansongtao complementfactorhval62ilevariantandriskofagerelatedmaculardegenerationametaanalysis
AT xieping complementfactorhval62ilevariantandriskofagerelatedmaculardegenerationametaanalysis
AT liuqinghuai complementfactorhval62ilevariantandriskofagerelatedmaculardegenerationametaanalysis