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Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes
TCRαβ thymocytes differentiate to either CD8αβ cytotoxic T lymphocytes or CD4(+) T helper cells. This functional dichotomy is controlled by key transcription factors, including the T helper master regulator, ThPOK, which suppresses the cytolytic program in MHC class II-restricted CD4(+) thymocytes....
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581083/ https://www.ncbi.nlm.nih.gov/pubmed/23334788 http://dx.doi.org/10.1038/ni.2523 |
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| author | Mucida, Daniel Husain, Mohammad Mushtaq Muroi, Sawako van Wijk, Femke Shinnakasu, Ryo Naoe, Yoshinori Reis, Bernardo Sgarbi Huang, Yujun Lambolez, Florence Docherty, Michael Attinger, Antoine Shui, Jr-Wen Kim, Gisen Lena, Christopher J. Sakaguchi, Shinya Miyamoto, Chizuko Wang, Peng Atarashi, Koji Park, Yunji Nakayama, Toshinori Honda, Kenya Ellmeier, Wilfried Kronenberg, Mitchell Taniuchi, Ichiro Cheroutre, Hilde |
| author_facet | Mucida, Daniel Husain, Mohammad Mushtaq Muroi, Sawako van Wijk, Femke Shinnakasu, Ryo Naoe, Yoshinori Reis, Bernardo Sgarbi Huang, Yujun Lambolez, Florence Docherty, Michael Attinger, Antoine Shui, Jr-Wen Kim, Gisen Lena, Christopher J. Sakaguchi, Shinya Miyamoto, Chizuko Wang, Peng Atarashi, Koji Park, Yunji Nakayama, Toshinori Honda, Kenya Ellmeier, Wilfried Kronenberg, Mitchell Taniuchi, Ichiro Cheroutre, Hilde |
| author_sort | Mucida, Daniel |
| collection | PubMed |
| description | TCRαβ thymocytes differentiate to either CD8αβ cytotoxic T lymphocytes or CD4(+) T helper cells. This functional dichotomy is controlled by key transcription factors, including the T helper master regulator, ThPOK, which suppresses the cytolytic program in MHC class II-restricted CD4(+) thymocytes. ThPOK continues to repress CD8-lineage genes in mature CD4(+) T cells, even as they differentiate to T helper effector subsets. Here we show that the T helper-fate was not fixed and that mature antigen-stimulated CD4(+) T cells could terminate Thpok expression and reactivate CD8-lineage genes. This unexpected plasticity resulted in the post-thymic termination of the T helper-program and the functional differentiation of distinct MHC class II-restricted CD4(+) cytotoxic T lymphocytes. |
| format | Online Article Text |
| id | pubmed-3581083 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-35810832013-09-01 Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes Mucida, Daniel Husain, Mohammad Mushtaq Muroi, Sawako van Wijk, Femke Shinnakasu, Ryo Naoe, Yoshinori Reis, Bernardo Sgarbi Huang, Yujun Lambolez, Florence Docherty, Michael Attinger, Antoine Shui, Jr-Wen Kim, Gisen Lena, Christopher J. Sakaguchi, Shinya Miyamoto, Chizuko Wang, Peng Atarashi, Koji Park, Yunji Nakayama, Toshinori Honda, Kenya Ellmeier, Wilfried Kronenberg, Mitchell Taniuchi, Ichiro Cheroutre, Hilde Nat Immunol Article TCRαβ thymocytes differentiate to either CD8αβ cytotoxic T lymphocytes or CD4(+) T helper cells. This functional dichotomy is controlled by key transcription factors, including the T helper master regulator, ThPOK, which suppresses the cytolytic program in MHC class II-restricted CD4(+) thymocytes. ThPOK continues to repress CD8-lineage genes in mature CD4(+) T cells, even as they differentiate to T helper effector subsets. Here we show that the T helper-fate was not fixed and that mature antigen-stimulated CD4(+) T cells could terminate Thpok expression and reactivate CD8-lineage genes. This unexpected plasticity resulted in the post-thymic termination of the T helper-program and the functional differentiation of distinct MHC class II-restricted CD4(+) cytotoxic T lymphocytes. 2013-01-20 2013-03 /pmc/articles/PMC3581083/ /pubmed/23334788 http://dx.doi.org/10.1038/ni.2523 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Mucida, Daniel Husain, Mohammad Mushtaq Muroi, Sawako van Wijk, Femke Shinnakasu, Ryo Naoe, Yoshinori Reis, Bernardo Sgarbi Huang, Yujun Lambolez, Florence Docherty, Michael Attinger, Antoine Shui, Jr-Wen Kim, Gisen Lena, Christopher J. Sakaguchi, Shinya Miyamoto, Chizuko Wang, Peng Atarashi, Koji Park, Yunji Nakayama, Toshinori Honda, Kenya Ellmeier, Wilfried Kronenberg, Mitchell Taniuchi, Ichiro Cheroutre, Hilde Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes |
| title | Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes |
| title_full | Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes |
| title_fullStr | Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes |
| title_full_unstemmed | Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes |
| title_short | Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes |
| title_sort | transcriptional reprogramming of mature cd4(+) t helper cells generates distinct mhc class ii-restricted cytotoxic t lymphocytes |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581083/ https://www.ncbi.nlm.nih.gov/pubmed/23334788 http://dx.doi.org/10.1038/ni.2523 |
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