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Microvesicles as Potential Ovarian Cancer Biomarkers

Although the incidence of ovarian cancer is low (i.e., less than 5% in European countries), it is the most lethal gynecologic malignancy and typically has a poor prognosis. To ensure optimal survival, it is important to diagnose this condition when the pathology is confined to the ovary. However, th...

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Detalles Bibliográficos
Autores principales: Giusti, Ilaria, D'Ascenzo, Sandra, Dolo, Vincenza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581088/
https://www.ncbi.nlm.nih.gov/pubmed/23484144
http://dx.doi.org/10.1155/2013/703048
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author Giusti, Ilaria
D'Ascenzo, Sandra
Dolo, Vincenza
author_facet Giusti, Ilaria
D'Ascenzo, Sandra
Dolo, Vincenza
author_sort Giusti, Ilaria
collection PubMed
description Although the incidence of ovarian cancer is low (i.e., less than 5% in European countries), it is the most lethal gynecologic malignancy and typically has a poor prognosis. To ensure optimal survival, it is important to diagnose this condition when the pathology is confined to the ovary. However, this is difficult to achieve because the first specific symptoms appear only during advanced disease stages. To date, the biomarker mainly used for the diagnosis and prognosis of ovarian cancer is CA125; however, this marker has a low sensitivity and specificity and is associated with several other physiological and pathological conditions. No other serum ovarian cancer markers appear to be able to replace or complement CA125, and the current challenge is therefore to identify novel markers for the early diagnosis of this disease. For this purpose, studies have focused on the microvesicles (MVs) released from tumor cells. MVs may represent an ideal biomarker because they can be easily isolated from blood, and they have particular features (mainly regarding microRNA profiles) that strongly correlate with ovarian cancer stage and may be effective for early diagnosis.
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spelling pubmed-35810882013-03-12 Microvesicles as Potential Ovarian Cancer Biomarkers Giusti, Ilaria D'Ascenzo, Sandra Dolo, Vincenza Biomed Res Int Review Article Although the incidence of ovarian cancer is low (i.e., less than 5% in European countries), it is the most lethal gynecologic malignancy and typically has a poor prognosis. To ensure optimal survival, it is important to diagnose this condition when the pathology is confined to the ovary. However, this is difficult to achieve because the first specific symptoms appear only during advanced disease stages. To date, the biomarker mainly used for the diagnosis and prognosis of ovarian cancer is CA125; however, this marker has a low sensitivity and specificity and is associated with several other physiological and pathological conditions. No other serum ovarian cancer markers appear to be able to replace or complement CA125, and the current challenge is therefore to identify novel markers for the early diagnosis of this disease. For this purpose, studies have focused on the microvesicles (MVs) released from tumor cells. MVs may represent an ideal biomarker because they can be easily isolated from blood, and they have particular features (mainly regarding microRNA profiles) that strongly correlate with ovarian cancer stage and may be effective for early diagnosis. Hindawi Publishing Corporation 2013 2013-01-08 /pmc/articles/PMC3581088/ /pubmed/23484144 http://dx.doi.org/10.1155/2013/703048 Text en Copyright © 2013 Ilaria Giusti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Giusti, Ilaria
D'Ascenzo, Sandra
Dolo, Vincenza
Microvesicles as Potential Ovarian Cancer Biomarkers
title Microvesicles as Potential Ovarian Cancer Biomarkers
title_full Microvesicles as Potential Ovarian Cancer Biomarkers
title_fullStr Microvesicles as Potential Ovarian Cancer Biomarkers
title_full_unstemmed Microvesicles as Potential Ovarian Cancer Biomarkers
title_short Microvesicles as Potential Ovarian Cancer Biomarkers
title_sort microvesicles as potential ovarian cancer biomarkers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581088/
https://www.ncbi.nlm.nih.gov/pubmed/23484144
http://dx.doi.org/10.1155/2013/703048
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