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The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects

BACKGROUND: Diabetes mellitus is a metabolic disorder characterized by increased production of free radicals and oxidative stress. The aim of this study was to evaluate the activity of antioxidant enzymes, superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxide (GSH-PX) in t...

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Autores principales: Taheri, Ehsaneh, Djalali, Mahmoud, Saedisomeolia, Ahmad, Moghadam, Ali Malekshahi, Djazayeri, Abolghasem, Qorbani, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581104/
https://www.ncbi.nlm.nih.gov/pubmed/23497678
http://dx.doi.org/10.1186/2251-6581-11-3
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author Taheri, Ehsaneh
Djalali, Mahmoud
Saedisomeolia, Ahmad
Moghadam, Ali Malekshahi
Djazayeri, Abolghasem
Qorbani, Mostafa
author_facet Taheri, Ehsaneh
Djalali, Mahmoud
Saedisomeolia, Ahmad
Moghadam, Ali Malekshahi
Djazayeri, Abolghasem
Qorbani, Mostafa
author_sort Taheri, Ehsaneh
collection PubMed
description BACKGROUND: Diabetes mellitus is a metabolic disorder characterized by increased production of free radicals and oxidative stress. The aim of this study was to evaluate the activity of antioxidant enzymes, superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxide (GSH-PX) in type 2 diabetic patients compared with healthy subjects. METHODS: This cross-sectional study was conducted on 100 type 2 diabetic patients and 100 healthy controls. Total antioxidant capacity and fasting serum levels of SOD, GR, and GSH-Px were measured. All data were analyzed using SPSS software compatible with Microsoft Windows. RESULTS: The activity levels of SOD were lower in diabetic patients (111.93 ± 354.99 U/g Hb) than in healthy controls (1158.53 ± 381.21 U/g Hb), but this was not significant. Activity levels of GSH-PX and GR in diabetics (62.33 ± 36.29 and 7.17 ± 5.51 U/g Hb, respectively) were higher than in controls (24.62 ± 11.2 and 3.16 ± 2.95 U/g Hb, respectively). The statistical difference in enzyme activity of both GSH-Px and GR was significant (P <0.05). CONCLUSION: The increasing production of free radicals and changes in activity levels of antioxidant enzymes in order to scavenge free radicals and/or the effect of diabetes on the activity levels of antioxidant enzymes has an important effect on diabetic complications and insulin resistance. Evaluation of the levels of antioxidant enzymes and antioxidant factors in patients at different stages of the disease, and pharmaceutical and nutritional interventions, can be helpful in reducing oxidative stress in type 2 diabetic patients. There were positive relationship between BMI and the activity of antioxidant enzymes including SOD, GR and GPX in both groups.
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spelling pubmed-35811042013-03-05 The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects Taheri, Ehsaneh Djalali, Mahmoud Saedisomeolia, Ahmad Moghadam, Ali Malekshahi Djazayeri, Abolghasem Qorbani, Mostafa J Diabetes Metab Disord Research Article BACKGROUND: Diabetes mellitus is a metabolic disorder characterized by increased production of free radicals and oxidative stress. The aim of this study was to evaluate the activity of antioxidant enzymes, superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxide (GSH-PX) in type 2 diabetic patients compared with healthy subjects. METHODS: This cross-sectional study was conducted on 100 type 2 diabetic patients and 100 healthy controls. Total antioxidant capacity and fasting serum levels of SOD, GR, and GSH-Px were measured. All data were analyzed using SPSS software compatible with Microsoft Windows. RESULTS: The activity levels of SOD were lower in diabetic patients (111.93 ± 354.99 U/g Hb) than in healthy controls (1158.53 ± 381.21 U/g Hb), but this was not significant. Activity levels of GSH-PX and GR in diabetics (62.33 ± 36.29 and 7.17 ± 5.51 U/g Hb, respectively) were higher than in controls (24.62 ± 11.2 and 3.16 ± 2.95 U/g Hb, respectively). The statistical difference in enzyme activity of both GSH-Px and GR was significant (P <0.05). CONCLUSION: The increasing production of free radicals and changes in activity levels of antioxidant enzymes in order to scavenge free radicals and/or the effect of diabetes on the activity levels of antioxidant enzymes has an important effect on diabetic complications and insulin resistance. Evaluation of the levels of antioxidant enzymes and antioxidant factors in patients at different stages of the disease, and pharmaceutical and nutritional interventions, can be helpful in reducing oxidative stress in type 2 diabetic patients. There were positive relationship between BMI and the activity of antioxidant enzymes including SOD, GR and GPX in both groups. BioMed Central 2012-08-02 /pmc/articles/PMC3581104/ /pubmed/23497678 http://dx.doi.org/10.1186/2251-6581-11-3 Text en Copyright ©2012 Taheri et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Taheri, Ehsaneh
Djalali, Mahmoud
Saedisomeolia, Ahmad
Moghadam, Ali Malekshahi
Djazayeri, Abolghasem
Qorbani, Mostafa
The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects
title The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects
title_full The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects
title_fullStr The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects
title_full_unstemmed The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects
title_short The relationship between the activates of antioxidant enzymes in red blood cells and body mass index in Iranian type 2 diabetes and healthy subjects
title_sort relationship between the activates of antioxidant enzymes in red blood cells and body mass index in iranian type 2 diabetes and healthy subjects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581104/
https://www.ncbi.nlm.nih.gov/pubmed/23497678
http://dx.doi.org/10.1186/2251-6581-11-3
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