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Parasitic Infections: A Role for C-Type Lectins Receptors

Antigen-presenting cells (APCs) sense the microenvironment through several types of receptors that recognize pathogen-associated molecular patterns. In particular, C-type lectins receptors (CLRs), which are expressed by distinct subsets of dendritic cells (DCs) and macrophages (MØs), recognize and i...

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Autores principales: Vázquez-Mendoza, Alicia, Carrero, Julio César, Rodriguez-Sosa, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581113/
https://www.ncbi.nlm.nih.gov/pubmed/23509724
http://dx.doi.org/10.1155/2013/456352
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author Vázquez-Mendoza, Alicia
Carrero, Julio César
Rodriguez-Sosa, Miriam
author_facet Vázquez-Mendoza, Alicia
Carrero, Julio César
Rodriguez-Sosa, Miriam
author_sort Vázquez-Mendoza, Alicia
collection PubMed
description Antigen-presenting cells (APCs) sense the microenvironment through several types of receptors that recognize pathogen-associated molecular patterns. In particular, C-type lectins receptors (CLRs), which are expressed by distinct subsets of dendritic cells (DCs) and macrophages (MØs), recognize and internalize specific carbohydrate antigens in a Ca(2+)-dependent manner. The targeting of these receptors is becoming an efficient strategy for parasite recognition. However, relatively little is known about how CLRs are involved in both pathogen recognition and the internalization of parasites. The role of CLRs in parasite infections is an area of considerable interest because this research will impact our understanding of the initiation of innate immune responses, which influences the outcome of specific immune responses. This paper attempts to summarize our understanding of the effects of parasites' interactions with CLRs.
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spelling pubmed-35811132013-03-18 Parasitic Infections: A Role for C-Type Lectins Receptors Vázquez-Mendoza, Alicia Carrero, Julio César Rodriguez-Sosa, Miriam Biomed Res Int Review Article Antigen-presenting cells (APCs) sense the microenvironment through several types of receptors that recognize pathogen-associated molecular patterns. In particular, C-type lectins receptors (CLRs), which are expressed by distinct subsets of dendritic cells (DCs) and macrophages (MØs), recognize and internalize specific carbohydrate antigens in a Ca(2+)-dependent manner. The targeting of these receptors is becoming an efficient strategy for parasite recognition. However, relatively little is known about how CLRs are involved in both pathogen recognition and the internalization of parasites. The role of CLRs in parasite infections is an area of considerable interest because this research will impact our understanding of the initiation of innate immune responses, which influences the outcome of specific immune responses. This paper attempts to summarize our understanding of the effects of parasites' interactions with CLRs. Hindawi Publishing Corporation 2013 2013-01-27 /pmc/articles/PMC3581113/ /pubmed/23509724 http://dx.doi.org/10.1155/2013/456352 Text en Copyright © 2013 Alicia Vázquez-Mendoza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vázquez-Mendoza, Alicia
Carrero, Julio César
Rodriguez-Sosa, Miriam
Parasitic Infections: A Role for C-Type Lectins Receptors
title Parasitic Infections: A Role for C-Type Lectins Receptors
title_full Parasitic Infections: A Role for C-Type Lectins Receptors
title_fullStr Parasitic Infections: A Role for C-Type Lectins Receptors
title_full_unstemmed Parasitic Infections: A Role for C-Type Lectins Receptors
title_short Parasitic Infections: A Role for C-Type Lectins Receptors
title_sort parasitic infections: a role for c-type lectins receptors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581113/
https://www.ncbi.nlm.nih.gov/pubmed/23509724
http://dx.doi.org/10.1155/2013/456352
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