Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

Chronic endoplasmic reticulum (ER) stress is a major contributor to obesity-induced insulin resistance in the liver. However, the molecular link between obesity and ER stress remains to be identified. Proteasomes are important multicatalytic enzyme complexes that degrade misfolded and oxidized prote...

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Detalles Bibliográficos
Autores principales: Otoda, Toshiki, Takamura, Toshinari, Misu, Hirofumi, Ota, Tsuguhito, Murata, Shigeo, Hayashi, Hiroto, Takayama, Hiroaki, Kikuchi, Akihiro, Kanamori, Takehiro, Shima, Kosuke R., Lan, Fei, Takeda, Takashi, Kurita, Seiichiro, Ishikura, Kazuhide, Kita, Yuki, Iwayama, Kaito, Kato, Ken-ichiro, Uno, Masafumi, Takeshita, Yumie, Yamamoto, Miyuki, Tokuyama, Kunpei, Iseki, Shoichi, Tanaka, Keiji, Kaneko, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581221/
https://www.ncbi.nlm.nih.gov/pubmed/23209186
http://dx.doi.org/10.2337/db11-1652

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