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Mitochondria and Cancer: Past, Present, and Future
The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581248/ https://www.ncbi.nlm.nih.gov/pubmed/23509753 http://dx.doi.org/10.1155/2013/612369 |
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author | Verschoor, M. L. Ungard, R. Harbottle, A. Jakupciak, J. P. Parr, R. L. Singh, G. |
author_facet | Verschoor, M. L. Ungard, R. Harbottle, A. Jakupciak, J. P. Parr, R. L. Singh, G. |
author_sort | Verschoor, M. L. |
collection | PubMed |
description | The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nuclear cell mate. Application of this holistic approach, to all metabolic interactions within the cell, is providing a more complete understanding of the molecular transformation of the cell from normal to malignant behavior, before histopathological indications are evident. In this review the surging momentum in mitochondrial science, as it relates to cancer, is described in three progressive perspectives: (1) Past: the historical contributions to current directions of research; (2) Present: Contemporary findings, results and approaches to mitochondria and cancer, including the role of next generation sequencing and proteomics; (3) Future: Based on the present body of knowledge, the potential assets and benefits of mitochondrial research are projected into the near future. |
format | Online Article Text |
id | pubmed-3581248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35812482013-03-18 Mitochondria and Cancer: Past, Present, and Future Verschoor, M. L. Ungard, R. Harbottle, A. Jakupciak, J. P. Parr, R. L. Singh, G. Biomed Res Int Review Article The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nuclear cell mate. Application of this holistic approach, to all metabolic interactions within the cell, is providing a more complete understanding of the molecular transformation of the cell from normal to malignant behavior, before histopathological indications are evident. In this review the surging momentum in mitochondrial science, as it relates to cancer, is described in three progressive perspectives: (1) Past: the historical contributions to current directions of research; (2) Present: Contemporary findings, results and approaches to mitochondria and cancer, including the role of next generation sequencing and proteomics; (3) Future: Based on the present body of knowledge, the potential assets and benefits of mitochondrial research are projected into the near future. Hindawi Publishing Corporation 2013 2013-01-28 /pmc/articles/PMC3581248/ /pubmed/23509753 http://dx.doi.org/10.1155/2013/612369 Text en Copyright © 2013 M. L. Verschoor et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Verschoor, M. L. Ungard, R. Harbottle, A. Jakupciak, J. P. Parr, R. L. Singh, G. Mitochondria and Cancer: Past, Present, and Future |
title | Mitochondria and Cancer: Past, Present, and Future |
title_full | Mitochondria and Cancer: Past, Present, and Future |
title_fullStr | Mitochondria and Cancer: Past, Present, and Future |
title_full_unstemmed | Mitochondria and Cancer: Past, Present, and Future |
title_short | Mitochondria and Cancer: Past, Present, and Future |
title_sort | mitochondria and cancer: past, present, and future |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581248/ https://www.ncbi.nlm.nih.gov/pubmed/23509753 http://dx.doi.org/10.1155/2013/612369 |
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