Cargando…

Mitochondria and Cancer: Past, Present, and Future

The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nu...

Descripción completa

Detalles Bibliográficos
Autores principales: Verschoor, M. L., Ungard, R., Harbottle, A., Jakupciak, J. P., Parr, R. L., Singh, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581248/
https://www.ncbi.nlm.nih.gov/pubmed/23509753
http://dx.doi.org/10.1155/2013/612369
_version_ 1782260393432842240
author Verschoor, M. L.
Ungard, R.
Harbottle, A.
Jakupciak, J. P.
Parr, R. L.
Singh, G.
author_facet Verschoor, M. L.
Ungard, R.
Harbottle, A.
Jakupciak, J. P.
Parr, R. L.
Singh, G.
author_sort Verschoor, M. L.
collection PubMed
description The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nuclear cell mate. Application of this holistic approach, to all metabolic interactions within the cell, is providing a more complete understanding of the molecular transformation of the cell from normal to malignant behavior, before histopathological indications are evident. In this review the surging momentum in mitochondrial science, as it relates to cancer, is described in three progressive perspectives: (1) Past: the historical contributions to current directions of research; (2) Present: Contemporary findings, results and approaches to mitochondria and cancer, including the role of next generation sequencing and proteomics; (3) Future: Based on the present body of knowledge, the potential assets and benefits of mitochondrial research are projected into the near future.
format Online
Article
Text
id pubmed-3581248
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35812482013-03-18 Mitochondria and Cancer: Past, Present, and Future Verschoor, M. L. Ungard, R. Harbottle, A. Jakupciak, J. P. Parr, R. L. Singh, G. Biomed Res Int Review Article The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nuclear cell mate. Application of this holistic approach, to all metabolic interactions within the cell, is providing a more complete understanding of the molecular transformation of the cell from normal to malignant behavior, before histopathological indications are evident. In this review the surging momentum in mitochondrial science, as it relates to cancer, is described in three progressive perspectives: (1) Past: the historical contributions to current directions of research; (2) Present: Contemporary findings, results and approaches to mitochondria and cancer, including the role of next generation sequencing and proteomics; (3) Future: Based on the present body of knowledge, the potential assets and benefits of mitochondrial research are projected into the near future. Hindawi Publishing Corporation 2013 2013-01-28 /pmc/articles/PMC3581248/ /pubmed/23509753 http://dx.doi.org/10.1155/2013/612369 Text en Copyright © 2013 M. L. Verschoor et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Verschoor, M. L.
Ungard, R.
Harbottle, A.
Jakupciak, J. P.
Parr, R. L.
Singh, G.
Mitochondria and Cancer: Past, Present, and Future
title Mitochondria and Cancer: Past, Present, and Future
title_full Mitochondria and Cancer: Past, Present, and Future
title_fullStr Mitochondria and Cancer: Past, Present, and Future
title_full_unstemmed Mitochondria and Cancer: Past, Present, and Future
title_short Mitochondria and Cancer: Past, Present, and Future
title_sort mitochondria and cancer: past, present, and future
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581248/
https://www.ncbi.nlm.nih.gov/pubmed/23509753
http://dx.doi.org/10.1155/2013/612369
work_keys_str_mv AT verschoorml mitochondriaandcancerpastpresentandfuture
AT ungardr mitochondriaandcancerpastpresentandfuture
AT harbottlea mitochondriaandcancerpastpresentandfuture
AT jakupciakjp mitochondriaandcancerpastpresentandfuture
AT parrrl mitochondriaandcancerpastpresentandfuture
AT singhg mitochondriaandcancerpastpresentandfuture