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Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects

Primary liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality. Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers. Major risk factors for HCC include infection with HBV or HCV, alcoholic liver disease, and most probabl...

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Autores principales: Yeh, Yao-Tsung, Chang, Chien-Wei, Wei, Ren-Jie, Wang, Shen-Nien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581253/
https://www.ncbi.nlm.nih.gov/pubmed/23484104
http://dx.doi.org/10.1155/2013/290575
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author Yeh, Yao-Tsung
Chang, Chien-Wei
Wei, Ren-Jie
Wang, Shen-Nien
author_facet Yeh, Yao-Tsung
Chang, Chien-Wei
Wei, Ren-Jie
Wang, Shen-Nien
author_sort Yeh, Yao-Tsung
collection PubMed
description Primary liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality. Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers. Major risk factors for HCC include infection with HBV or HCV, alcoholic liver disease, and most probably nonalcoholic fatty liver disease. In general, men are two to four times more often associated with HCC than women. It can be suggested that sex hormones including progesterone may play some roles in HCC. Rather, very limited information discusses its potential involvement in HCC. This paper thus collects some recent studies of the potential involvement of progesterone and related compounds in HCC from basic and clinical aspects. In addition, two synthetic progestins, megestrol acetate (MA) and medroxyprogesterone acetate (MPA), will be discussed thoroughly. It is noted that progesterone can also serve as the precursor for androgens and estrogens produced by the gonadal and adrenal cortical tissues, while men have a higher incidence of HCC than women might be due to the stimulatory effects of androgen and the protective effects of estrogen. Eventually, this paper suggests a new insight on the associations of progesterone and related compounds with HCC development and treatment.
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spelling pubmed-35812532013-03-12 Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects Yeh, Yao-Tsung Chang, Chien-Wei Wei, Ren-Jie Wang, Shen-Nien Biomed Res Int Review Article Primary liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality. Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers. Major risk factors for HCC include infection with HBV or HCV, alcoholic liver disease, and most probably nonalcoholic fatty liver disease. In general, men are two to four times more often associated with HCC than women. It can be suggested that sex hormones including progesterone may play some roles in HCC. Rather, very limited information discusses its potential involvement in HCC. This paper thus collects some recent studies of the potential involvement of progesterone and related compounds in HCC from basic and clinical aspects. In addition, two synthetic progestins, megestrol acetate (MA) and medroxyprogesterone acetate (MPA), will be discussed thoroughly. It is noted that progesterone can also serve as the precursor for androgens and estrogens produced by the gonadal and adrenal cortical tissues, while men have a higher incidence of HCC than women might be due to the stimulatory effects of androgen and the protective effects of estrogen. Eventually, this paper suggests a new insight on the associations of progesterone and related compounds with HCC development and treatment. Hindawi Publishing Corporation 2013 2013-01-16 /pmc/articles/PMC3581253/ /pubmed/23484104 http://dx.doi.org/10.1155/2013/290575 Text en Copyright © 2013 Yao-Tsung Yeh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yeh, Yao-Tsung
Chang, Chien-Wei
Wei, Ren-Jie
Wang, Shen-Nien
Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
title Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
title_full Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
title_fullStr Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
title_full_unstemmed Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
title_short Progesterone and Related Compounds in Hepatocellular Carcinoma: Basic and Clinical Aspects
title_sort progesterone and related compounds in hepatocellular carcinoma: basic and clinical aspects
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581253/
https://www.ncbi.nlm.nih.gov/pubmed/23484104
http://dx.doi.org/10.1155/2013/290575
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