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Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update
The pathogenesis and treatment of inflammatory bowel disease (IBD) have been recently advanced, while it is still challenged with high morbidity and poor prognosis. Infliximab, a monoclonal antibody of tumor necrosis factor (TNF), has emerged as an efficient treatment with many clinical benefits suc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581271/ https://www.ncbi.nlm.nih.gov/pubmed/23484133 http://dx.doi.org/10.1155/2013/581631 |
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author | Guo, Yuan Lu, Nonghua Bai, Aiping |
author_facet | Guo, Yuan Lu, Nonghua Bai, Aiping |
author_sort | Guo, Yuan |
collection | PubMed |
description | The pathogenesis and treatment of inflammatory bowel disease (IBD) have been recently advanced, while it is still challenged with high morbidity and poor prognosis. Infliximab, a monoclonal antibody of tumor necrosis factor (TNF), has emerged as an efficient treatment with many clinical benefits such as quick disease activity reduction and IBD patient life quality improvement. However, the biological effects of infliximab on IBD need to be elucidated. This paper reviewed the clinical use and recently advanced biological action of infliximab on IBD. By forming the stable complex with the soluble or the membrane form of TNF in fluid environment or on cell surface of immune cell, fibroblast, endothelium, and epithelium, infliximab quenches TNF activity and performs the important biological actions which lead to amelioration and remission of immune responses. The mechanisms of infliximab treatment for IBD were intensively discussed. The recent advances on two topics including predictors and side effects of infliximab treatment were also reviewed. |
format | Online Article Text |
id | pubmed-3581271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35812712013-03-12 Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update Guo, Yuan Lu, Nonghua Bai, Aiping Biomed Res Int Review Article The pathogenesis and treatment of inflammatory bowel disease (IBD) have been recently advanced, while it is still challenged with high morbidity and poor prognosis. Infliximab, a monoclonal antibody of tumor necrosis factor (TNF), has emerged as an efficient treatment with many clinical benefits such as quick disease activity reduction and IBD patient life quality improvement. However, the biological effects of infliximab on IBD need to be elucidated. This paper reviewed the clinical use and recently advanced biological action of infliximab on IBD. By forming the stable complex with the soluble or the membrane form of TNF in fluid environment or on cell surface of immune cell, fibroblast, endothelium, and epithelium, infliximab quenches TNF activity and performs the important biological actions which lead to amelioration and remission of immune responses. The mechanisms of infliximab treatment for IBD were intensively discussed. The recent advances on two topics including predictors and side effects of infliximab treatment were also reviewed. Hindawi Publishing Corporation 2013 2013-01-21 /pmc/articles/PMC3581271/ /pubmed/23484133 http://dx.doi.org/10.1155/2013/581631 Text en Copyright © 2013 Yuan Guo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Guo, Yuan Lu, Nonghua Bai, Aiping Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update |
title | Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update |
title_full | Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update |
title_fullStr | Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update |
title_full_unstemmed | Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update |
title_short | Clinical Use and Mechanisms of Infliximab Treatment on Inflammatory Bowel Disease: A Recent Update |
title_sort | clinical use and mechanisms of infliximab treatment on inflammatory bowel disease: a recent update |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581271/ https://www.ncbi.nlm.nih.gov/pubmed/23484133 http://dx.doi.org/10.1155/2013/581631 |
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