Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing

Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cell...

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Detalles Bibliográficos
Autores principales: Xu, Fanxing, Zhang, Chenying, Graves, Dana T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581278/
https://www.ncbi.nlm.nih.gov/pubmed/23484152
http://dx.doi.org/10.1155/2013/754802
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author Xu, Fanxing
Zhang, Chenying
Graves, Dana T.
author_facet Xu, Fanxing
Zhang, Chenying
Graves, Dana T.
author_sort Xu, Fanxing
collection PubMed
description Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α.
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spelling pubmed-35812782013-03-12 Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing Xu, Fanxing Zhang, Chenying Graves, Dana T. Biomed Res Int Review Article Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF-α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF-α. Hindawi Publishing Corporation 2013 2013-01-20 /pmc/articles/PMC3581278/ /pubmed/23484152 http://dx.doi.org/10.1155/2013/754802 Text en Copyright © 2013 Fanxing Xu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Fanxing
Zhang, Chenying
Graves, Dana T.
Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing
title Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing
title_full Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing
title_fullStr Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing
title_full_unstemmed Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing
title_short Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing
title_sort abnormal cell responses and role of tnf-α in impaired diabetic wound healing
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581278/
https://www.ncbi.nlm.nih.gov/pubmed/23484152
http://dx.doi.org/10.1155/2013/754802
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