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High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats
To establish the role of the metabolic state in the pathogenesis of polyneuropathy, an age- and sex-matched, longitudinal study in rats fed high-fat and high-sucrose diets (HFSD) or high-fat, high-sucrose and high-salt diets (HFSSD) relative to controls was performed. Time courses of body weight, sy...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581455/ https://www.ncbi.nlm.nih.gov/pubmed/23451227 http://dx.doi.org/10.1371/journal.pone.0057427 |
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author | Xie, Fang Fu, Han Hou, Jun-Feng Jiao, Kai Costigan, Michael Chen, Jun |
author_facet | Xie, Fang Fu, Han Hou, Jun-Feng Jiao, Kai Costigan, Michael Chen, Jun |
author_sort | Xie, Fang |
collection | PubMed |
description | To establish the role of the metabolic state in the pathogenesis of polyneuropathy, an age- and sex-matched, longitudinal study in rats fed high-fat and high-sucrose diets (HFSD) or high-fat, high-sucrose and high-salt diets (HFSSD) relative to controls was performed. Time courses of body weight, systolic blood pressure, fasting plasma glucose (FPG), insulin, free fatty acids (FFA), homeostasis model assessment-insulin resistance index (HOMA-IR), thermal and mechanical sensitivity and motor coordination were measured in parallel. Finally, large and small myelinated fibers (LMF, SMF) as well as unmyelinated fibers (UMF) in the sciatic nerves and ascending fibers in the spinal dorsal column were quantitatively assessed under electron microscopy. The results showed that early metabolic syndrome (hyperinsulinemia, dyslipidemia, and hypertension) and prediabetic conditions (impaired fasting glucose) could be induced by high energy diet, and these animals later developed painful polyneuropathy characterized by myelin breakdown and LMF loss in both peripheral and central nervous system. In contrast SMF and UMF in the sciatic nerves were changed little, in the same animals. Therefore the phenomenon that high energy diets induce bilateral mechanical, but not thermal, pain hypersensitivity is reflected by severe damage to LMF, but mild damage to SMF and UMF. Moreover, dietary sodium (high-salt) deteriorates the neuropathic pathological process induced by high energy diets, but paradoxically high salt consumption, may reduce, at least temporarily, chronic pain perception in these animals. |
format | Online Article Text |
id | pubmed-3581455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35814552013-02-28 High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats Xie, Fang Fu, Han Hou, Jun-Feng Jiao, Kai Costigan, Michael Chen, Jun PLoS One Research Article To establish the role of the metabolic state in the pathogenesis of polyneuropathy, an age- and sex-matched, longitudinal study in rats fed high-fat and high-sucrose diets (HFSD) or high-fat, high-sucrose and high-salt diets (HFSSD) relative to controls was performed. Time courses of body weight, systolic blood pressure, fasting plasma glucose (FPG), insulin, free fatty acids (FFA), homeostasis model assessment-insulin resistance index (HOMA-IR), thermal and mechanical sensitivity and motor coordination were measured in parallel. Finally, large and small myelinated fibers (LMF, SMF) as well as unmyelinated fibers (UMF) in the sciatic nerves and ascending fibers in the spinal dorsal column were quantitatively assessed under electron microscopy. The results showed that early metabolic syndrome (hyperinsulinemia, dyslipidemia, and hypertension) and prediabetic conditions (impaired fasting glucose) could be induced by high energy diet, and these animals later developed painful polyneuropathy characterized by myelin breakdown and LMF loss in both peripheral and central nervous system. In contrast SMF and UMF in the sciatic nerves were changed little, in the same animals. Therefore the phenomenon that high energy diets induce bilateral mechanical, but not thermal, pain hypersensitivity is reflected by severe damage to LMF, but mild damage to SMF and UMF. Moreover, dietary sodium (high-salt) deteriorates the neuropathic pathological process induced by high energy diets, but paradoxically high salt consumption, may reduce, at least temporarily, chronic pain perception in these animals. Public Library of Science 2013-02-25 /pmc/articles/PMC3581455/ /pubmed/23451227 http://dx.doi.org/10.1371/journal.pone.0057427 Text en © 2013 Xie et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Xie, Fang Fu, Han Hou, Jun-Feng Jiao, Kai Costigan, Michael Chen, Jun High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats |
title | High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats |
title_full | High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats |
title_fullStr | High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats |
title_full_unstemmed | High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats |
title_short | High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats |
title_sort | high energy diets-induced metabolic and prediabetic painful polyneuropathy in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581455/ https://www.ncbi.nlm.nih.gov/pubmed/23451227 http://dx.doi.org/10.1371/journal.pone.0057427 |
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