Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma

Normal tissues express the M1 isoform of pyruvate kinase (PK) that helps generate and funnel pyruvate into the mitochondria for ATP production. Tumors, in contrast, express the less active PKM2 isoform, which limits pyruvate production and spares glycolytic intermediates for the generation of macrom...

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Detalles Bibliográficos
Autores principales: Mukherjee, Joydeep, Phillips, Joanna J., Zheng, Shichun, Wiencke, John, Ronen, Sabrina M., Pieper, Russell O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581484/
https://www.ncbi.nlm.nih.gov/pubmed/23451252
http://dx.doi.org/10.1371/journal.pone.0057610

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