Cargando…
Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease
BACKGROUND: Patients with chronic kidney disease have an increased cardiovascular risk that is not fully explained by traditional risk factors but appears to be related to increased arterial stiffness. Cytomegalovirus (CMV) infection is associated with increased cardiovascular risk although the mech...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581505/ https://www.ncbi.nlm.nih.gov/pubmed/23451030 http://dx.doi.org/10.1371/journal.pone.0055686 |
_version_ | 1782260424929968128 |
---|---|
author | Wall, Nadezhda A. Chue, Colin D. Edwards, Nicola C. Pankhurst, Tanya Harper, Lorraine Steeds, Richard P. Lauder, Sarah Townend, Jonathan N. Moss, Paul Ferro, Charles J. |
author_facet | Wall, Nadezhda A. Chue, Colin D. Edwards, Nicola C. Pankhurst, Tanya Harper, Lorraine Steeds, Richard P. Lauder, Sarah Townend, Jonathan N. Moss, Paul Ferro, Charles J. |
author_sort | Wall, Nadezhda A. |
collection | PubMed |
description | BACKGROUND: Patients with chronic kidney disease have an increased cardiovascular risk that is not fully explained by traditional risk factors but appears to be related to increased arterial stiffness. Cytomegalovirus (CMV) infection is associated with increased cardiovascular risk although the mechanisms for this are unknown. We examined whether CMV seropositivity was associated with increased arterial stiffness in patients with chronic kidney disease. METHODOLOGY AND PRINCIPAL FINDINGS: In 215 non-diabetic patients with chronic kidney disease, CMV seropositivity was determined using an anti-CMV IgG ELISA. Pulse wave velocity was measured and aortic distensibility assessed in the ascending, proximal descending and distal descending thoracic aorta. Patients seropositive for CMV had a higher pulse wave velocity and lower aortic distensibility at all 3 levels. These differences (except for ascending aortic distensibility) persisted in a subcohort matched for age, gender and renal function, and when the whole cohort was divided into quartiles of age. In multivariable analyses, CMV seropositivity was an independent determinant of pulse wave velocity and proximal and distal descending aortic distensibility. CONCLUSIONS: In patients with chronic kidney disease, CMV seropositivity is associated with increased arterial stiffness and decreased distensibility of the proximal descending and distal aorta. These findings suggest that further research is required to examine CMV as a possible cause of arterial disease and increased cardiovascular risk in patients with CKD and may be relevant more widely for CMV seropositive patients with normal renal function. |
format | Online Article Text |
id | pubmed-3581505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35815052013-02-28 Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease Wall, Nadezhda A. Chue, Colin D. Edwards, Nicola C. Pankhurst, Tanya Harper, Lorraine Steeds, Richard P. Lauder, Sarah Townend, Jonathan N. Moss, Paul Ferro, Charles J. PLoS One Research Article BACKGROUND: Patients with chronic kidney disease have an increased cardiovascular risk that is not fully explained by traditional risk factors but appears to be related to increased arterial stiffness. Cytomegalovirus (CMV) infection is associated with increased cardiovascular risk although the mechanisms for this are unknown. We examined whether CMV seropositivity was associated with increased arterial stiffness in patients with chronic kidney disease. METHODOLOGY AND PRINCIPAL FINDINGS: In 215 non-diabetic patients with chronic kidney disease, CMV seropositivity was determined using an anti-CMV IgG ELISA. Pulse wave velocity was measured and aortic distensibility assessed in the ascending, proximal descending and distal descending thoracic aorta. Patients seropositive for CMV had a higher pulse wave velocity and lower aortic distensibility at all 3 levels. These differences (except for ascending aortic distensibility) persisted in a subcohort matched for age, gender and renal function, and when the whole cohort was divided into quartiles of age. In multivariable analyses, CMV seropositivity was an independent determinant of pulse wave velocity and proximal and distal descending aortic distensibility. CONCLUSIONS: In patients with chronic kidney disease, CMV seropositivity is associated with increased arterial stiffness and decreased distensibility of the proximal descending and distal aorta. These findings suggest that further research is required to examine CMV as a possible cause of arterial disease and increased cardiovascular risk in patients with CKD and may be relevant more widely for CMV seropositive patients with normal renal function. Public Library of Science 2013-02-25 /pmc/articles/PMC3581505/ /pubmed/23451030 http://dx.doi.org/10.1371/journal.pone.0055686 Text en © 2013 Wall et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wall, Nadezhda A. Chue, Colin D. Edwards, Nicola C. Pankhurst, Tanya Harper, Lorraine Steeds, Richard P. Lauder, Sarah Townend, Jonathan N. Moss, Paul Ferro, Charles J. Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease |
title | Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease |
title_full | Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease |
title_fullStr | Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease |
title_full_unstemmed | Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease |
title_short | Cytomegalovirus Seropositivity Is Associated with Increased Arterial Stiffness in Patients with Chronic Kidney Disease |
title_sort | cytomegalovirus seropositivity is associated with increased arterial stiffness in patients with chronic kidney disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581505/ https://www.ncbi.nlm.nih.gov/pubmed/23451030 http://dx.doi.org/10.1371/journal.pone.0055686 |
work_keys_str_mv | AT wallnadezhdaa cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT chuecolind cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT edwardsnicolac cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT pankhursttanya cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT harperlorraine cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT steedsrichardp cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT laudersarah cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT townendjonathann cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT mosspaul cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease AT ferrocharlesj cytomegalovirusseropositivityisassociatedwithincreasedarterialstiffnessinpatientswithchronickidneydisease |