DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands

Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the opt...

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Detalles Bibliográficos
Autor principal: Winssinger, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581508/
https://www.ncbi.nlm.nih.gov/pubmed/22871882
http://dx.doi.org/10.4161/adna.21108
Descripción
Sumario:Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions.

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