DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands

Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the opt...

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Detalles Bibliográficos
Autor principal: Winssinger, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581508/
https://www.ncbi.nlm.nih.gov/pubmed/22871882
http://dx.doi.org/10.4161/adna.21108
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author Winssinger, Nicolas
author_facet Winssinger, Nicolas
author_sort Winssinger, Nicolas
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description Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions.
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spelling pubmed-35815082013-02-28 DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands Winssinger, Nicolas Artif DNA PNA XNA Commentary Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions. Landes Bioscience 2012-07-01 /pmc/articles/PMC3581508/ /pubmed/22871882 http://dx.doi.org/10.4161/adna.21108 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Winssinger, Nicolas
DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands
title DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands
title_full DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands
title_fullStr DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands
title_full_unstemmed DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands
title_short DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands
title_sort dna display of pna-tagged ligands: a versatile strategy to screen libraries and control geometry of multidentate ligands
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581508/
https://www.ncbi.nlm.nih.gov/pubmed/22871882
http://dx.doi.org/10.4161/adna.21108
work_keys_str_mv AT winssingernicolas dnadisplayofpnataggedligandsaversatilestrategytoscreenlibrariesandcontrolgeometryofmultidentateligands

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