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DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands
Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the opt...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581508/ https://www.ncbi.nlm.nih.gov/pubmed/22871882 http://dx.doi.org/10.4161/adna.21108 |