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Molecular Dynamics Reveal Binding Mode of Glutathionylspermidine by Trypanothione Synthetase

The trypanothione synthetase (TryS) catalyses the two-step biosynthesis of trypanothione from spermidine and glutathione and is an attractive new drug target for the development of trypanocidal and antileishmanial drugs, especially since the structural information of TryS from Leishmania major has b...

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Detalles Bibliográficos
Autores principales:	Koch, Oliver, Cappel, Daniel, Nocker, Monika, Jäger, Timo, Flohé, Leopold, Sotriffer, Christoph A., Selzer, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581523/ https://www.ncbi.nlm.nih.gov/pubmed/23451087 http://dx.doi.org/10.1371/journal.pone.0056788

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