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Predominance of HA-222D/G Polymorphism in Influenza A(H1N1)pdm09 Viruses Associated with Fatal and Severe Outcomes Recently Circulating in Germany

Influenza A(H1N1)pdm09 viruses cause sporadically very severe disease including fatal clinical outcomes associated with pneumonia, viremia and myocarditis. A mutation characterized by the substitution of aspartic acid (wild-type) to glycine at position 222 within the haemagglutinin gene (HA-D222G) w...

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Detalles Bibliográficos
Autores principales: Wedde, Marianne, Wählisch, Stephanie, Wolff, Thorsten, Schweiger, Brunhilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581548/
https://www.ncbi.nlm.nih.gov/pubmed/23451145
http://dx.doi.org/10.1371/journal.pone.0057059