Paclitaxel Resistance and Multicellular Spheroid Formation Are Induced by Kallikrein-Related Peptidase 4 in Serous Ovarian Cancer Cells in an Ascites Mimicking Microenvironment

High tumor kallikrein-related-peptidase 4 (KLK4) levels are associated with a poor outcome for women with serous epithelial ovarian cancer (EOC), for which peritoneal dissemination and chemoresistance are key events. To determine the role of KLK4 in these events, we examined KLK4-transfected SKOV-3...

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Detalles Bibliográficos
Autores principales: Dong, Ying, Stephens, Carson, Walpole, Carina, Swedberg, Joakim E., Boyle, Glen M., Parsons, Peter G., McGuckin, Michael A., Harris, Jonathan M., Clements, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581584/
https://www.ncbi.nlm.nih.gov/pubmed/23451143
http://dx.doi.org/10.1371/journal.pone.0057056

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