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Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence

BACKGROUND: A clinical need exists to improve identification of those who will sustain fragility fractures. Individuals with both osteoporosis (OP) and sarcopenia (SP), so-called “sarco-osteoporosis” (SOP), might be at higher fracture risk than those with OP or SP alone. Approaches to facilitate SOP...

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Autores principales: Buehring, Bjoern, Krueger, Diane, Binkley, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581618/
https://www.ncbi.nlm.nih.gov/pubmed/22872366
http://dx.doi.org/10.1007/s13539-012-0080-8
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author Buehring, Bjoern
Krueger, Diane
Binkley, Neil
author_facet Buehring, Bjoern
Krueger, Diane
Binkley, Neil
author_sort Buehring, Bjoern
collection PubMed
description BACKGROUND: A clinical need exists to improve identification of those who will sustain fragility fractures. Individuals with both osteoporosis (OP) and sarcopenia (SP), so-called “sarco-osteoporosis” (SOP), might be at higher fracture risk than those with OP or SP alone. Approaches to facilitate SOP identification, e.g., use of tallest historical rather than current height and inclusion of radius bone mineral density (BMD) measurement, may be of benefit. This study examined the effect of advancing age on SOP prevalence with and without use of historical tallest height and radius BMD measurement. METHODS: Adults age 60+ underwent dual-energy X-ray absorptiometry (DXA) BMD and total body composition measurement. OP and SP were defined using standard criteria: T-score ≤−2.5 at the lumbar spine or hip and appendicular lean mass (ALM)/current height(2) <5.45 kg/m(2) (female) and <7.26 kg/m(2) (male). Proposed “sensitive” SP criteria used historical tallest height instead of current height, while “sensitive” OP criteria added the 1/3(rd) radius T-score. The primary outcome was SOP prevalence by decade (60–69, 70–79, 80+). RESULTS: A total of 304 individuals (146 M/158 F) participated. OP, SP and SOP prevalence were higher in older adults and increased (p < 0.05) with the “sensitive” criteria. SOP prevalence was lower than that of OP or SP and increased (standard/sensitive) criteria from 1.1 % / 4.5 % in the 60–69 years age group to 10.4 % / 21.9 % in the 80+ years age group. CONCLUSIONS: SOP prevalence is higher in older adults. Use of historical tallest height and 1/3(rd) radius BMD increases SOP prevalence. Future studies need to assess whether having SOP increases fracture risk and whether use of tallest height and/or one-third radius BMD improves fracture risk prediction.
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spelling pubmed-35816182013-03-01 Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence Buehring, Bjoern Krueger, Diane Binkley, Neil J Cachexia Sarcopenia Muscle Original Article BACKGROUND: A clinical need exists to improve identification of those who will sustain fragility fractures. Individuals with both osteoporosis (OP) and sarcopenia (SP), so-called “sarco-osteoporosis” (SOP), might be at higher fracture risk than those with OP or SP alone. Approaches to facilitate SOP identification, e.g., use of tallest historical rather than current height and inclusion of radius bone mineral density (BMD) measurement, may be of benefit. This study examined the effect of advancing age on SOP prevalence with and without use of historical tallest height and radius BMD measurement. METHODS: Adults age 60+ underwent dual-energy X-ray absorptiometry (DXA) BMD and total body composition measurement. OP and SP were defined using standard criteria: T-score ≤−2.5 at the lumbar spine or hip and appendicular lean mass (ALM)/current height(2) <5.45 kg/m(2) (female) and <7.26 kg/m(2) (male). Proposed “sensitive” SP criteria used historical tallest height instead of current height, while “sensitive” OP criteria added the 1/3(rd) radius T-score. The primary outcome was SOP prevalence by decade (60–69, 70–79, 80+). RESULTS: A total of 304 individuals (146 M/158 F) participated. OP, SP and SOP prevalence were higher in older adults and increased (p < 0.05) with the “sensitive” criteria. SOP prevalence was lower than that of OP or SP and increased (standard/sensitive) criteria from 1.1 % / 4.5 % in the 60–69 years age group to 10.4 % / 21.9 % in the 80+ years age group. CONCLUSIONS: SOP prevalence is higher in older adults. Use of historical tallest height and 1/3(rd) radius BMD increases SOP prevalence. Future studies need to assess whether having SOP increases fracture risk and whether use of tallest height and/or one-third radius BMD improves fracture risk prediction. Springer-Verlag 2012-08-08 2013-03 /pmc/articles/PMC3581618/ /pubmed/22872366 http://dx.doi.org/10.1007/s13539-012-0080-8 Text en © Springer-Verlag 2012
spellingShingle Original Article
Buehring, Bjoern
Krueger, Diane
Binkley, Neil
Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence
title Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence
title_full Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence
title_fullStr Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence
title_full_unstemmed Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence
title_short Effect of including historical height and radius BMD measurement on sarco-osteoporosis prevalence
title_sort effect of including historical height and radius bmd measurement on sarco-osteoporosis prevalence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581618/
https://www.ncbi.nlm.nih.gov/pubmed/22872366
http://dx.doi.org/10.1007/s13539-012-0080-8
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