Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

α(2)-Macroglobulin (α(2)M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of α(2)M with proteases results in an ‘activated’ conformation, where the proteases become covalently-linked within the interior of a cage-like structure formed by α(2)M....

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Detalles Bibliográficos
Autores principales: Wyatt, Amy R., Constantinescu, Patrick, Ecroyd, Heath, Dobson, Christopher M., Wilson, Mark R., Kumita, Janet R., Yerbury, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581772/
https://www.ncbi.nlm.nih.gov/pubmed/23353684
http://dx.doi.org/10.1016/j.febslet.2013.01.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581772/
https://www.ncbi.nlm.nih.gov/pubmed/23353684
http://dx.doi.org/10.1016/j.febslet.2013.01.020

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