Cargando…
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms
α(2)-Macroglobulin (α(2)M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of α(2)M with proteases results in an ‘activated’ conformation, where the proteases become covalently-linked within the interior of a cage-like structure formed by α(2)M....
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science B.V
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581772/ https://www.ncbi.nlm.nih.gov/pubmed/23353684 http://dx.doi.org/10.1016/j.febslet.2013.01.020 |