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Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model
The purpose of this study was to assess the relationship between size and the continuity of energy application in interstitial laser-induced thermotherapy. Percutaneous computed tomography-guided laser ablation (30 W, 600 nm diode) of the lung was performed in 7 Yorkshire pigs; a total of 42 ablatio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
e-Med
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581868/ https://www.ncbi.nlm.nih.gov/pubmed/23439016 http://dx.doi.org/10.1102/1470-7330.2013.0002 |
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author | Schoellnast, Helmut Monette, Sebastien Ezell, Paula C. Keene, Andrew Quehenberger, Franz Erinjeri, Joseph P. Solomon, Stephen B. |
author_facet | Schoellnast, Helmut Monette, Sebastien Ezell, Paula C. Keene, Andrew Quehenberger, Franz Erinjeri, Joseph P. Solomon, Stephen B. |
author_sort | Schoellnast, Helmut |
collection | PubMed |
description | The purpose of this study was to assess the relationship between size and the continuity of energy application in interstitial laser-induced thermotherapy. Percutaneous computed tomography-guided laser ablation (30 W, 600 nm diode) of the lung was performed in 7 Yorkshire pigs; a total of 42 ablation zones were created. Twenty ablations were performed using a continuous cycle of 2 min (protocol A) and 22 ablations were performed using 4 intermittent cycles with a duration of 1 min for each cycle interrupted by a 10-s stop between the cycles (protocol B). The lung was harvested immediately after euthanasia for gross pathology and histopathologic evaluation. Statistical analysis was performed using the Student t test and the Spearman correlation coefficient. Laser ablation resulted in complete necrosis of variable size of lung. The mean ablation zone dimensions (±SD) were 1.9 (±0.4) cm × 1.4 (±0.3) cm for protocol A and 2.2 (±0.5) cm × 1.4 (±0.4) cm for protocol B. The size of the necrosis is not significantly different when comparing a continuous 2-min ablation to a 4-cycle intermittent ablation for 1 min each cycle interrupted by a 10-s stop between the cycles (P = 0.98 and 0.53, respectively). |
format | Online Article Text |
id | pubmed-3581868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | e-Med |
record_format | MEDLINE/PubMed |
spelling | pubmed-35818682014-06-13 Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model Schoellnast, Helmut Monette, Sebastien Ezell, Paula C. Keene, Andrew Quehenberger, Franz Erinjeri, Joseph P. Solomon, Stephen B. Cancer Imaging Original Article The purpose of this study was to assess the relationship between size and the continuity of energy application in interstitial laser-induced thermotherapy. Percutaneous computed tomography-guided laser ablation (30 W, 600 nm diode) of the lung was performed in 7 Yorkshire pigs; a total of 42 ablation zones were created. Twenty ablations were performed using a continuous cycle of 2 min (protocol A) and 22 ablations were performed using 4 intermittent cycles with a duration of 1 min for each cycle interrupted by a 10-s stop between the cycles (protocol B). The lung was harvested immediately after euthanasia for gross pathology and histopathologic evaluation. Statistical analysis was performed using the Student t test and the Spearman correlation coefficient. Laser ablation resulted in complete necrosis of variable size of lung. The mean ablation zone dimensions (±SD) were 1.9 (±0.4) cm × 1.4 (±0.3) cm for protocol A and 2.2 (±0.5) cm × 1.4 (±0.4) cm for protocol B. The size of the necrosis is not significantly different when comparing a continuous 2-min ablation to a 4-cycle intermittent ablation for 1 min each cycle interrupted by a 10-s stop between the cycles (P = 0.98 and 0.53, respectively). e-Med 2013-02-22 /pmc/articles/PMC3581868/ /pubmed/23439016 http://dx.doi.org/10.1102/1470-7330.2013.0002 Text en © 2013 International Cancer Imaging Society |
spellingShingle | Original Article Schoellnast, Helmut Monette, Sebastien Ezell, Paula C. Keene, Andrew Quehenberger, Franz Erinjeri, Joseph P. Solomon, Stephen B. Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model |
title | Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model |
title_full | Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model |
title_fullStr | Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model |
title_full_unstemmed | Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model |
title_short | Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model |
title_sort | interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581868/ https://www.ncbi.nlm.nih.gov/pubmed/23439016 http://dx.doi.org/10.1102/1470-7330.2013.0002 |
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