The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

Ser/thr phosphatases dephosphorylate their targets with high specificity, yet the structural and sequence determinants of phosphosite recognition are poorly understood. Calcineurin (CN) is a conserved Ca(2+)/calmodulin-dependent ser/thr phosphatase and the target of immunosuppressants, FK506 and cyc...

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Detalles Bibliográficos
Autores principales: Grigoriu, Simina, Bond, Rachel, Cossio, Pilar, Chen, Jennifer A., Ly, Nina, Hummer, Gerhard, Page, Rebecca, Cyert, Martha S., Peti, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582496/
https://www.ncbi.nlm.nih.gov/pubmed/23468591
http://dx.doi.org/10.1371/journal.pbio.1001492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582496/
https://www.ncbi.nlm.nih.gov/pubmed/23468591
http://dx.doi.org/10.1371/journal.pbio.1001492

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