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The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin
Ser/thr phosphatases dephosphorylate their targets with high specificity, yet the structural and sequence determinants of phosphosite recognition are poorly understood. Calcineurin (CN) is a conserved Ca(2+)/calmodulin-dependent ser/thr phosphatase and the target of immunosuppressants, FK506 and cyc...
Autores principales: | Grigoriu, Simina, Bond, Rachel, Cossio, Pilar, Chen, Jennifer A., Ly, Nina, Hummer, Gerhard, Page, Rebecca, Cyert, Martha S., Peti, Wolfgang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582496/ https://www.ncbi.nlm.nih.gov/pubmed/23468591 http://dx.doi.org/10.1371/journal.pbio.1001492 |
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