Cargando…

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

Ser/thr phosphatases dephosphorylate their targets with high specificity, yet the structural and sequence determinants of phosphosite recognition are poorly understood. Calcineurin (CN) is a conserved Ca(2+)/calmodulin-dependent ser/thr phosphatase and the target of immunosuppressants, FK506 and cyc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grigoriu, Simina, Bond, Rachel, Cossio, Pilar, Chen, Jennifer A., Ly, Nina, Hummer, Gerhard, Page, Rebecca, Cyert, Martha S., Peti, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582496/ https://www.ncbi.nlm.nih.gov/pubmed/23468591 http://dx.doi.org/10.1371/journal.pbio.1001492

Ejemplares similares

The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin
por: Li, Yang, et al.
Publicado: (2020)

Calcineurin, the Ca(2+)-dependent phosphatase, regulates Rga2, a Cdc42 GTPase-activating protein, to modulate pheromone signaling
por: Ly, Nina, et al.
Publicado: (2017)

Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM
por: Sheftic, Sarah R., et al.
Publicado: (2016)

Three Dimensional Structure of the MqsR:MqsA Complex: A Novel TA Pair Comprised of a Toxin Homologous to RelE and an Antitoxin with Unique Properties
por: Brown, Breann L., et al.
Publicado: (2009)

Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p
por: Polizotto, Renée S., et al.
Publicado: (2001)

Hcm1 integrates signals from Cdk1 and calcineurin to control cell proliferation
por: Arsenault, Heather E., et al.
Publicado: (2015)

Calcineurin associates with centrosomes and regulates cilia length maintenance
por: Tsekitsidou, Eirini, et al.
Publicado: (2023)

Calcineurin regulates the yeast synaptojanin Inp53/Sjl3 during membrane stress
por: Guiney, Evan L., et al.
Publicado: (2015)

Structural and Functional Analysis of the NLRP4 Pyrin Domain
por: Eibl, Clarissa, et al.
Publicado: (2012)

Molecular basis for the binding and selective dephosphorylation of Na(+)/H(+) exchanger 1 by calcineurin
por: Hendus-Altenburger, Ruth, et al.
Publicado: (2019)

Transition paths in single-molecule force spectroscopy
por: Cossio, Pilar, et al.
Publicado: (2018)

MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding
por: Yu, Victor, et al.
Publicado: (2022)

Spinophilin directs Protein Phosphatase 1 specificity by blocking substrate binding sites
por: Ragusa, Michael J., et al.
Publicado: (2010)

Everolimus Based Immunosuppression Strategies in Adult Lung Transplant Recipients: Calcineurin Inhibitor Minimization Versus Calcineurin Inhibitor Elimination
por: Ivulich, Steven, et al.
Publicado: (2023)

Immunosuppression with Calcineurin Inhibitor after Renal Transplant Failure Inhibits Allosensitization
por: López del Moral Cuesta, Covadonga, et al.
Publicado: (2020)

Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?
por: Vymazal, Ondřej, et al.
Publicado: (2021)

Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells
por: Colombo, Miriam, et al.
Publicado: (2022)

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane
por: Ulengin-Talkish, Idil, et al.
Publicado: (2021)

Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells
por: Yilmaz, Duygu Elif, et al.
Publicado: (2022)

Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy
por: Bendickova, Kamila, et al.
Publicado: (2017)

Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme
por: Kumar, Ganesan Senthil, et al.
Publicado: (2018)

FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia
por: Ianiri, Giuseppe, et al.
Publicado: (2017)

Enhancing Beta Cell Replacement Therapies: Exploring Calcineurin Inhibitor-Sparing Immunosuppressive Regimens
por: Caldara, Rossana, et al.
Publicado: (2023)

A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment
por: Wang, Xinru, et al.
Publicado: (2020)

Validation tests for cryo-EM maps using an independent particle set
por: Ortiz, Sebastian, et al.
Publicado: (2020)

The mode of action of the Protein tyrosine phosphatase 1B inhibitor Ertiprotafib
por: Kumar, Ganesan Senthil, et al.
Publicado: (2020)

Formaldehyde exposure induces regulatory T cell-mediated immunosuppression via calcineurin-NFAT signalling pathway
por: Park, Jeongsik, et al.
Publicado: (2020)

Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti rats
por: Brosda, Jan, et al.
Publicado: (2020)

Differential effects of the immunosuppressive calcineurin inhibitors cyclosporine-A and tacrolimus on ovulation in a murine model
por: Zakerkish, F, et al.
Publicado: (2021)

Introducing ‘Open Questions’ article type
por: Cyert, Martha S.
Publicado: (2020)

Calcineurin
por: Creamer, Trevor P.
Publicado: (2020)

Evidence for the Immunosuppressive Potential of Calcineurin Inhibitor-Sparing Regimens in Liver Transplant Recipients with Impaired Renal Function
por: Ide, Kentaro, et al.
Publicado: (2011)

Crystal structures of the DExH-box RNA helicase DHX9
por: Lee, Young-Tae, et al.
Publicado: (2023)

Immunosuppressive regimens based on Cyclophospamide or Calcineurin inhibitors: Comparison of their effect in the long term outcome of Primary Membranous Nephropathy
por: Stangou, Maria, et al.
Publicado: (2019)

Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy
por: Cavagna, Lorenzo, et al.
Publicado: (2020)

Treatment of De Novo Renal Transplant Recipients With Calcineurin Inhibitor–free, Belatacept Plus Everolimus–based Immunosuppression
por: Peddi, V. Ram, et al.
Publicado: (2023)

Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologue
por: Denis, Valérie, et al.
Publicado: (2002)

Renal impairment after liver transplantation - a pilot trial of calcineurin inhibitor-free vs. calcineurin inhibitor sparing immunosuppression in patients with mildly impaired renal function after liver transplantation
por: Gerhardt, T, et al.
Publicado: (2009)

Calcineurin Participation in Hebbian and Homeostatic Plasticity Associated With Extinction
por: Reyes-García, Salma E., et al.
Publicado: (2021)

A Calcineurin-Hoxb13 Axis Regulates Growth Mode of Mammalian Cardiomyocytes
por: Nguyen, Ngoc Uyen Nhi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jscel18p7mt262dg83ss8a65ca