Fibroblast Growth Factor Receptors-1 and -3 Play Distinct Roles in the Regulation of Bladder Cancer Growth and Metastasis: Implications for Therapeutic Targeting

Fibroblast growth factor receptors (FGFRs) are activated by mutation and overexpressed in bladder cancers (BCs), and FGFR inhibitors are currently being evaluated in clinical trials in BC patients. However, BC cells display marked heterogeneity in their responses to FGFR inhibitors, and the biologic...

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Detalles Bibliográficos
Autores principales: Cheng, Tiewei, Roth, Beat, Choi, Woonyoung, Black, Peter C., Dinney, Colin, McConkey, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582560/
https://www.ncbi.nlm.nih.gov/pubmed/23468956
http://dx.doi.org/10.1371/journal.pone.0057284

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