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Instability of CTG Repeats is Governed by the Position of a DNA Base Lesion through Base Excision Repair
Trinucleotide repeat (TNR) expansions and deletions are associated with human neurodegeneration and cancer. However, their underlying mechanisms remain to be elucidated. Recent studies have demonstrated that CAG repeat expansions can be initiated by oxidative DNA base damage and fulfilled by base ex...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582642/ https://www.ncbi.nlm.nih.gov/pubmed/23468897 http://dx.doi.org/10.1371/journal.pone.0056960 |