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The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals

Nuclear receptor interacting protein (Nrip1), also known as RIP140, is a co-regulator for nuclear receptors that plays an essential role in ovulation by regulating the expression of the epidermal growth factor-like family of growth factors. Although several studies indicate a role for RIP140 in brea...

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Autores principales: Nautiyal, Jaya, Steel, Jennifer H., Mane, Meritxell Rosell, Oduwole, Olayiwola, Poliandri, Ariel, Alexi, Xanthippi, Wood, Nicholas, Poutanen, Matti, Zwart, Wilbert, Stingl, John, Parker, Malcolm G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Company of Biologists 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583043/
https://www.ncbi.nlm.nih.gov/pubmed/23404106
http://dx.doi.org/10.1242/dev.085720
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author Nautiyal, Jaya
Steel, Jennifer H.
Mane, Meritxell Rosell
Oduwole, Olayiwola
Poliandri, Ariel
Alexi, Xanthippi
Wood, Nicholas
Poutanen, Matti
Zwart, Wilbert
Stingl, John
Parker, Malcolm G.
author_facet Nautiyal, Jaya
Steel, Jennifer H.
Mane, Meritxell Rosell
Oduwole, Olayiwola
Poliandri, Ariel
Alexi, Xanthippi
Wood, Nicholas
Poutanen, Matti
Zwart, Wilbert
Stingl, John
Parker, Malcolm G.
author_sort Nautiyal, Jaya
collection PubMed
description Nuclear receptor interacting protein (Nrip1), also known as RIP140, is a co-regulator for nuclear receptors that plays an essential role in ovulation by regulating the expression of the epidermal growth factor-like family of growth factors. Although several studies indicate a role for RIP140 in breast cancer, its role in the development of the mammary gland is unclear. By using RIP140-null and RIP140 transgenic mice, we demonstrate that RIP140 is an essential factor for normal mammary gland development and that it functions by mediating oestrogen signalling. RIP140-null mice exhibit minimal ductal elongation with no side-branching, whereas RIP140-overexpressing mice show increased cell proliferation and ductal branching with age. Tissue recombination experiments demonstrate that RIP140 expression is required in both the mammary epithelial and stromal compartments for ductal elongation during puberty and that loss of RIP140 leads to a catastrophic loss of the mammary epithelium, whereas RIP140 overexpression augments the mammary basal cell population and shifts the progenitor/differentiated cell balance within the luminal cell compartment towards the progenitors. For the first time, we present a genome-wide global view of oestrogen receptor-α (ERα) binding events in the developing mammary gland, which unravels 881 ERα binding sites. Unbiased evaluation of several ERα binding sites for RIP140 co-occupancy reveals selectivity and demonstrates that RIP140 acts as a co-regulator with ERα to regulate directly the expression of amphiregulin (Areg), the progesterone receptor (Pgr) and signal transducer and activator of transcription 5a (Stat5a), factors that influence key mitogenic pathways that regulate normal mammary gland development.
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spelling pubmed-35830432013-03-15 The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals Nautiyal, Jaya Steel, Jennifer H. Mane, Meritxell Rosell Oduwole, Olayiwola Poliandri, Ariel Alexi, Xanthippi Wood, Nicholas Poutanen, Matti Zwart, Wilbert Stingl, John Parker, Malcolm G. Development Research Articles Nuclear receptor interacting protein (Nrip1), also known as RIP140, is a co-regulator for nuclear receptors that plays an essential role in ovulation by regulating the expression of the epidermal growth factor-like family of growth factors. Although several studies indicate a role for RIP140 in breast cancer, its role in the development of the mammary gland is unclear. By using RIP140-null and RIP140 transgenic mice, we demonstrate that RIP140 is an essential factor for normal mammary gland development and that it functions by mediating oestrogen signalling. RIP140-null mice exhibit minimal ductal elongation with no side-branching, whereas RIP140-overexpressing mice show increased cell proliferation and ductal branching with age. Tissue recombination experiments demonstrate that RIP140 expression is required in both the mammary epithelial and stromal compartments for ductal elongation during puberty and that loss of RIP140 leads to a catastrophic loss of the mammary epithelium, whereas RIP140 overexpression augments the mammary basal cell population and shifts the progenitor/differentiated cell balance within the luminal cell compartment towards the progenitors. For the first time, we present a genome-wide global view of oestrogen receptor-α (ERα) binding events in the developing mammary gland, which unravels 881 ERα binding sites. Unbiased evaluation of several ERα binding sites for RIP140 co-occupancy reveals selectivity and demonstrates that RIP140 acts as a co-regulator with ERα to regulate directly the expression of amphiregulin (Areg), the progesterone receptor (Pgr) and signal transducer and activator of transcription 5a (Stat5a), factors that influence key mitogenic pathways that regulate normal mammary gland development. Company of Biologists 2013-03-01 /pmc/articles/PMC3583043/ /pubmed/23404106 http://dx.doi.org/10.1242/dev.085720 Text en © 2013. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by-nc-sa/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
spellingShingle Research Articles
Nautiyal, Jaya
Steel, Jennifer H.
Mane, Meritxell Rosell
Oduwole, Olayiwola
Poliandri, Ariel
Alexi, Xanthippi
Wood, Nicholas
Poutanen, Matti
Zwart, Wilbert
Stingl, John
Parker, Malcolm G.
The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals
title The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals
title_full The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals
title_fullStr The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals
title_full_unstemmed The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals
title_short The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals
title_sort transcriptional co-factor rip140 regulates mammary gland development by promoting the generation of key mitogenic signals
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583043/
https://www.ncbi.nlm.nih.gov/pubmed/23404106
http://dx.doi.org/10.1242/dev.085720
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