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Why I Am Not SHY: A Reply to Tononi and Cirelli
In a recent article I reviewed an influential theory of sleep function, the “synaptic homeostasis hypothesis (SHY.)” According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep fun...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583075/ https://www.ncbi.nlm.nih.gov/pubmed/23476811 http://dx.doi.org/10.1155/2013/394946 |
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author | Frank, Marcos Gabriel |
author_facet | Frank, Marcos Gabriel |
author_sort | Frank, Marcos Gabriel |
collection | PubMed |
description | In a recent article I reviewed an influential theory of sleep function, the “synaptic homeostasis hypothesis (SHY.)” According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep function and the brain, its underlying mechanisms are poorly defined. In an accompanying article, the authors of SHY responded at length. Their reply is thoughtful and provocative, but unfortunately many of the points I raised were not accurately represented or addressed. In this brief commentary, I attempt to clarify some points of confusion. I also explain why any theory of sleep function is incomplete without an understanding of the underlying cellular mechanisms. |
format | Online Article Text |
id | pubmed-3583075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35830752013-03-09 Why I Am Not SHY: A Reply to Tononi and Cirelli Frank, Marcos Gabriel Neural Plast Letter to the Editor In a recent article I reviewed an influential theory of sleep function, the “synaptic homeostasis hypothesis (SHY.)” According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep function and the brain, its underlying mechanisms are poorly defined. In an accompanying article, the authors of SHY responded at length. Their reply is thoughtful and provocative, but unfortunately many of the points I raised were not accurately represented or addressed. In this brief commentary, I attempt to clarify some points of confusion. I also explain why any theory of sleep function is incomplete without an understanding of the underlying cellular mechanisms. Hindawi Publishing Corporation 2013 2013-02-12 /pmc/articles/PMC3583075/ /pubmed/23476811 http://dx.doi.org/10.1155/2013/394946 Text en Copyright © 2013 Marcos Gabriel Frank. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Letter to the Editor Frank, Marcos Gabriel Why I Am Not SHY: A Reply to Tononi and Cirelli |
title | Why I Am Not SHY: A Reply to Tononi and Cirelli |
title_full | Why I Am Not SHY: A Reply to Tononi and Cirelli |
title_fullStr | Why I Am Not SHY: A Reply to Tononi and Cirelli |
title_full_unstemmed | Why I Am Not SHY: A Reply to Tononi and Cirelli |
title_short | Why I Am Not SHY: A Reply to Tononi and Cirelli |
title_sort | why i am not shy: a reply to tononi and cirelli |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583075/ https://www.ncbi.nlm.nih.gov/pubmed/23476811 http://dx.doi.org/10.1155/2013/394946 |
work_keys_str_mv | AT frankmarcosgabriel whyiamnotshyareplytotononiandcirelli |