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Why I Am Not SHY: A Reply to Tononi and Cirelli

In a recent article I reviewed an influential theory of sleep function, the “synaptic homeostasis hypothesis (SHY.)” According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep fun...

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Autor principal: Frank, Marcos Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583075/
https://www.ncbi.nlm.nih.gov/pubmed/23476811
http://dx.doi.org/10.1155/2013/394946
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author Frank, Marcos Gabriel
author_facet Frank, Marcos Gabriel
author_sort Frank, Marcos Gabriel
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description In a recent article I reviewed an influential theory of sleep function, the “synaptic homeostasis hypothesis (SHY.)” According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep function and the brain, its underlying mechanisms are poorly defined. In an accompanying article, the authors of SHY responded at length. Their reply is thoughtful and provocative, but unfortunately many of the points I raised were not accurately represented or addressed. In this brief commentary, I attempt to clarify some points of confusion. I also explain why any theory of sleep function is incomplete without an understanding of the underlying cellular mechanisms.
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spelling pubmed-35830752013-03-09 Why I Am Not SHY: A Reply to Tononi and Cirelli Frank, Marcos Gabriel Neural Plast Letter to the Editor In a recent article I reviewed an influential theory of sleep function, the “synaptic homeostasis hypothesis (SHY.)” According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep function and the brain, its underlying mechanisms are poorly defined. In an accompanying article, the authors of SHY responded at length. Their reply is thoughtful and provocative, but unfortunately many of the points I raised were not accurately represented or addressed. In this brief commentary, I attempt to clarify some points of confusion. I also explain why any theory of sleep function is incomplete without an understanding of the underlying cellular mechanisms. Hindawi Publishing Corporation 2013 2013-02-12 /pmc/articles/PMC3583075/ /pubmed/23476811 http://dx.doi.org/10.1155/2013/394946 Text en Copyright © 2013 Marcos Gabriel Frank. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Frank, Marcos Gabriel
Why I Am Not SHY: A Reply to Tononi and Cirelli
title Why I Am Not SHY: A Reply to Tononi and Cirelli
title_full Why I Am Not SHY: A Reply to Tononi and Cirelli
title_fullStr Why I Am Not SHY: A Reply to Tononi and Cirelli
title_full_unstemmed Why I Am Not SHY: A Reply to Tononi and Cirelli
title_short Why I Am Not SHY: A Reply to Tononi and Cirelli
title_sort why i am not shy: a reply to tononi and cirelli
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583075/
https://www.ncbi.nlm.nih.gov/pubmed/23476811
http://dx.doi.org/10.1155/2013/394946
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