A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma

This is a case report of a previously undescribed 20q chromosomal deletion (del(20q)) in marginal zone lymphoma (MZL). A 54-year-old Caucasian male presented with an enlarging neck mass and multiple violaceous skin nodules over his chest. Biopsy of the neck mass and cervical lymph nodes revealed MZL...

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Autores principales: Kern, Jason B., Duff, Deiter J., Odem, Jamie L., Esebua, Magda, Smith, Lisa R., Doll, Donald, Wang, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583111/
https://www.ncbi.nlm.nih.gov/pubmed/23476863
http://dx.doi.org/10.1155/2013/784176
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author Kern, Jason B.
Duff, Deiter J.
Odem, Jamie L.
Esebua, Magda
Smith, Lisa R.
Doll, Donald
Wang, Michael
author_facet Kern, Jason B.
Duff, Deiter J.
Odem, Jamie L.
Esebua, Magda
Smith, Lisa R.
Doll, Donald
Wang, Michael
author_sort Kern, Jason B.
collection PubMed
description This is a case report of a previously undescribed 20q chromosomal deletion (del(20q)) in marginal zone lymphoma (MZL). A 54-year-old Caucasian male presented with an enlarging neck mass and multiple violaceous skin nodules over his chest. Biopsy of the neck mass and cervical lymph nodes revealed MZL. Cytogenetic evaluation of both lymph node and bone marrow tissue revealed del(20q). This was an unexpected finding, as del(20q) is associated with myelodysplastic syndromes and myeloproliferative neoplasms and rarely seen in diffuse large B-cell lymphoma, follicular lymphoma, and T-cell lymphoma, but has not previously been described in MZL. We describe the case presentation and histologic findings and discuss the significance of this novel finding.
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spelling pubmed-35831112013-03-09 A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma Kern, Jason B. Duff, Deiter J. Odem, Jamie L. Esebua, Magda Smith, Lisa R. Doll, Donald Wang, Michael Case Rep Pathol Case Report This is a case report of a previously undescribed 20q chromosomal deletion (del(20q)) in marginal zone lymphoma (MZL). A 54-year-old Caucasian male presented with an enlarging neck mass and multiple violaceous skin nodules over his chest. Biopsy of the neck mass and cervical lymph nodes revealed MZL. Cytogenetic evaluation of both lymph node and bone marrow tissue revealed del(20q). This was an unexpected finding, as del(20q) is associated with myelodysplastic syndromes and myeloproliferative neoplasms and rarely seen in diffuse large B-cell lymphoma, follicular lymphoma, and T-cell lymphoma, but has not previously been described in MZL. We describe the case presentation and histologic findings and discuss the significance of this novel finding. Hindawi Publishing Corporation 2013 2013-02-12 /pmc/articles/PMC3583111/ /pubmed/23476863 http://dx.doi.org/10.1155/2013/784176 Text en Copyright © 2013 Jason B. Kern et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kern, Jason B.
Duff, Deiter J.
Odem, Jamie L.
Esebua, Magda
Smith, Lisa R.
Doll, Donald
Wang, Michael
A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma
title A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma
title_full A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma
title_fullStr A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma
title_full_unstemmed A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma
title_short A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma
title_sort novel del(20q) in aggressive nodal marginal zone lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583111/
https://www.ncbi.nlm.nih.gov/pubmed/23476863
http://dx.doi.org/10.1155/2013/784176
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