Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential

This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed...

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Detalles Bibliográficos
Autores principales: Lima, Larissa Lavorato, Lima, Rebeca Mól, da Silva, Annelisa Farah, do Carmo, Antônio Márcio Resende, da Silva, Adilson David, Raposo, Nádia Rezende Barbosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583142/
https://www.ncbi.nlm.nih.gov/pubmed/23476126
http://dx.doi.org/10.1155/2013/274643
Descripción
Sumario:This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA(50) = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P < 0.001). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring.

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