Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential

This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed...

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Autores principales: Lima, Larissa Lavorato, Lima, Rebeca Mól, da Silva, Annelisa Farah, do Carmo, Antônio Márcio Resende, da Silva, Adilson David, Raposo, Nádia Rezende Barbosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583142/
https://www.ncbi.nlm.nih.gov/pubmed/23476126
http://dx.doi.org/10.1155/2013/274643
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author Lima, Larissa Lavorato
Lima, Rebeca Mól
da Silva, Annelisa Farah
do Carmo, Antônio Márcio Resende
da Silva, Adilson David
Raposo, Nádia Rezende Barbosa
author_facet Lima, Larissa Lavorato
Lima, Rebeca Mól
da Silva, Annelisa Farah
do Carmo, Antônio Márcio Resende
da Silva, Adilson David
Raposo, Nádia Rezende Barbosa
author_sort Lima, Larissa Lavorato
collection PubMed
description This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA(50) = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P < 0.001). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring.
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spelling pubmed-35831422013-03-09 Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential Lima, Larissa Lavorato Lima, Rebeca Mól da Silva, Annelisa Farah do Carmo, Antônio Márcio Resende da Silva, Adilson David Raposo, Nádia Rezende Barbosa ScientificWorldJournal Research Article This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA(50) = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol (P < 0.001). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring. Hindawi Publishing Corporation 2013-02-12 /pmc/articles/PMC3583142/ /pubmed/23476126 http://dx.doi.org/10.1155/2013/274643 Text en Copyright © 2013 Larissa Lavorato Lima et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lima, Larissa Lavorato
Lima, Rebeca Mól
da Silva, Annelisa Farah
do Carmo, Antônio Márcio Resende
da Silva, Adilson David
Raposo, Nádia Rezende Barbosa
Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential
title Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential
title_full Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential
title_fullStr Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential
title_full_unstemmed Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential
title_short Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential
title_sort azastilbene analogs as tyrosinase inhibitors: new molecules with depigmenting potential
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583142/
https://www.ncbi.nlm.nih.gov/pubmed/23476126
http://dx.doi.org/10.1155/2013/274643
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