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Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments
BACKGROUND: Treatment of solid tumors with vascular disrupting agent OXi4503 results in over 90% tumor destruction. However, a thin rim of viable cells persists in the tumor periphery following treatment, contributing to subsequent recurrence. This study investigates inherent differences in the micr...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583184/ https://www.ncbi.nlm.nih.gov/pubmed/23153292 http://dx.doi.org/10.1186/1471-2407-12-522 |