Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation

BACKGROUND: Phosphorylation-dephosphorylation cycles (PDCs) mediated by kinases and phosphatases are common in cellular signalling. Kinetic modelling of PDCs has shown that these systems can exhibit a variety of input-output (dose-response) behaviors including graded response, ultrasensitivity and b...

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Detalles Bibliográficos
Autores principales: Szomolay, Barbara, Shahrezaei, Vahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583237/
https://www.ncbi.nlm.nih.gov/pubmed/22531112
http://dx.doi.org/10.1186/1752-0509-6-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583237/
https://www.ncbi.nlm.nih.gov/pubmed/22531112
http://dx.doi.org/10.1186/1752-0509-6-26

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