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Hit identification of IKKβ natural product inhibitor
BACKGROUND: The nuclear factor-κB (NF-κB) proteins are a small group of heterodimeric transcription factors that play an important role in regulating the inflammatory, immune, and apoptotic responses. NF-κB activity is suppressed by association with the inhibitor IκB. Aberrant NF-κB signaling activi...
Autores principales: | Leung, Chung-Hang, Chan, Daniel Shiu-Hin, Li, Ying-Wei, Fong, Wang-Fun, Ma, Dik-Lung |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583241/ https://www.ncbi.nlm.nih.gov/pubmed/23294515 http://dx.doi.org/10.1186/2050-6511-14-3 |
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