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miRNAs in breast cancer tumorigenesis (Review)
miRNAs are small, endogenous, non-coding RNAs that negatively regulate protein-coding mRNAs at the post-transcriptional level. It is estimated that in humans thousands of miRNAs are expressed and more than 700 miRNAs have been described to date. About 50% of annotated human miRNAs are detected in re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583555/ https://www.ncbi.nlm.nih.gov/pubmed/22200848 http://dx.doi.org/10.3892/or.2011.1611 |
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author | ZHANG, ZHONG JU MA, SHI LIANG |
author_facet | ZHANG, ZHONG JU MA, SHI LIANG |
author_sort | ZHANG, ZHONG JU |
collection | PubMed |
description | miRNAs are small, endogenous, non-coding RNAs that negatively regulate protein-coding mRNAs at the post-transcriptional level. It is estimated that in humans thousands of miRNAs are expressed and more than 700 miRNAs have been described to date. About 50% of annotated human miRNAs are detected in regions of fragile sites, which are associated with cancer. The available evidence has shown that miRNAs widely participate in the development or progression of many types of cancers, including breast cancer. The role of miRNAs in breast cancer has been widely investigated; here, we will focus on what is known about the working mechanism of miRNAs in different stages of breast cancer development. |
format | Online Article Text |
id | pubmed-3583555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-35835552013-02-28 miRNAs in breast cancer tumorigenesis (Review) ZHANG, ZHONG JU MA, SHI LIANG Oncol Rep Articles miRNAs are small, endogenous, non-coding RNAs that negatively regulate protein-coding mRNAs at the post-transcriptional level. It is estimated that in humans thousands of miRNAs are expressed and more than 700 miRNAs have been described to date. About 50% of annotated human miRNAs are detected in regions of fragile sites, which are associated with cancer. The available evidence has shown that miRNAs widely participate in the development or progression of many types of cancers, including breast cancer. The role of miRNAs in breast cancer has been widely investigated; here, we will focus on what is known about the working mechanism of miRNAs in different stages of breast cancer development. D.A. Spandidos 2011-12-23 2012-04 /pmc/articles/PMC3583555/ /pubmed/22200848 http://dx.doi.org/10.3892/or.2011.1611 Text en Copyright © 2012, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles ZHANG, ZHONG JU MA, SHI LIANG miRNAs in breast cancer tumorigenesis (Review) |
title | miRNAs in breast cancer tumorigenesis (Review) |
title_full | miRNAs in breast cancer tumorigenesis (Review) |
title_fullStr | miRNAs in breast cancer tumorigenesis (Review) |
title_full_unstemmed | miRNAs in breast cancer tumorigenesis (Review) |
title_short | miRNAs in breast cancer tumorigenesis (Review) |
title_sort | mirnas in breast cancer tumorigenesis (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583555/ https://www.ncbi.nlm.nih.gov/pubmed/22200848 http://dx.doi.org/10.3892/or.2011.1611 |
work_keys_str_mv | AT zhangzhongju mirnasinbreastcancertumorigenesisreview AT mashiliang mirnasinbreastcancertumorigenesisreview |