Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells

The Werner (WRN) gene codes for a DNA helicase that contributes to genomic stability and has been identified as the gene responsible for progeria. Recent studies have shown reduced WRN expression due to aberrant DNA hypermethylation in cancer cells. Furthermore, WRN expression is thought to affect s...

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Detalles Bibliográficos
Autores principales: MASUDA, KENTA, BANNO, KOUJI, YANOKURA, MEGUMI, TSUJI, KOSUKE, KOBAYASHI, YUSUKE, KISU, IORI, UEKI, ARISA, YAMAGAMI, WATARU, NOMURA, HIROYUKI, TOMINAGA, EIICHIRO, SUSUMU, NOBUYUKI, AOKI, DAISUKE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583574/
https://www.ncbi.nlm.nih.gov/pubmed/22797812
http://dx.doi.org/10.3892/or.2012.1912

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